Is Butyl Hydroxybutyrate safe in cosmetics?
Butyl Hydroxybutyrate has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Butyl Hydroxybutyrate
INCI: BUTYL HYDROXYBUTYRATE
Butyl Hydroxybutyrate (CAS 53605-94-0) is a cosmetic cosmetic ingredient functioning as Solvent. Reported NOAEL =1000 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 53605-94-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Butyl Hydroxybutyrate is prohibited in EU cosmetics but has active industrial GHS classifications (H319).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Solvent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
butyl 3-hydroxybutanoate
InChIKey
LHDWRKCOQQHAMP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Insufficient standalone data. MoS calculation would require read-across from analogous hydroxybutyrate esters. Likely favorable given low use concentrations as solvent.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Butyl Hydroxybutyrate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Butyl Hydroxybutyrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Cleaning agent
Solvent
Regulatory List Membership (1)
EPA Safer Chemical Ingredients List (SCIL)
Expert Verdict
Expert safety assessment and concern-level summary for Butyl Hydroxybutyrate.
Regulatory Flags
epa_safer_alternative
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Butyl Hydroxybutyrate by CAS number or substance name.
Studies
1
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Chemical Function
Solvent
Cleaning agent
Regulatory Lists
SCIL (9/2019)
SCIL (9/2019)
Frequently Asked Questions
Is Butyl Hydroxybutyrate allowed in the EU?
Butyl Hydroxybutyrate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Butyl Hydroxybutyrate do in cosmetics?
Butyl Hydroxybutyrate functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 53605-94-0.
What is the NOAEL for Butyl Hydroxybutyrate?
The NOAEL (No Observed Adverse Effect Level) for Butyl Hydroxybutyrate is =1000 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Butyl Hydroxybutyrate used outside cosmetics?
Butyl Hydroxybutyrate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Butyl Hydroxybutyrate have different safety status in cosmetics vs industrial chemicals?
Butyl Hydroxybutyrate is prohibited in EU cosmetics but has active industrial GHS classifications (H319).
Compliance Tools
Check Butyl Hydroxybutyrate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
C10-13 Isoparaffin
Excellent
Same category
Solvent
C9-14 Isoparaffin
Excellent
Same category
Solvent
PPG-10 Butanediol
Excellent
Same category
Solvent
Phosphate Buffered Saline
Excellent
Same category
Solvent, buffering agent
Water
Excellent
Same category
Solvent, vehicle/carrier
1,10-Decanediol
Good
Same category
Solvent
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
BUTENE
Good
Browse nearby
Not Reported
BUTYL 2-METHYLBUTYRATE
Good
Browse nearby
Perfuming
BUTYL ACRYLATE/C6-14 PERFLUOROALKYLETHYL ACRYLATE/MERCAPTOPROPYL DIMETHICONE COPOLYMER
Good
Browse nearby
Film Forming, Opacifying
Is Butyl Hydroxybutyrate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Butyl Hydroxybutyrate in your formulation.