INCI: BISHYDROXYETHYL BISCETYL MALONAMIDE
Bishydroxyethyl Biscetyl Malonamide (CAS 149591-38-8) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent (ceramide mimic / pseudo-ceramide); used in skin. Reported NOAEL =15 mg/kg/day (SCCS Opinion); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 149591-38-8 →
Bishydroxyethyl Biscetyl Malonamide is prohibited in EU cosmetics but has active industrial GHS classifications (H319, H361f, H413).
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Bishydroxyethyl Biscetyl Malonamide.
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4 study endpoints found for Bishydroxyethyl Biscetyl Malonamide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =15 mg/kg/day | oral | - | repeated dose toxicity | SCCS Opinion |
| NOAEL | =15 mg/kg/day | oral | - | repeated dose toxicity | SCCS Opinion |
| NOAEL | =15 mg/kg/day | oral | - | repeated dose toxicity | SCCS Opinion |
| NOAEL | =15 mg/kg/day | oral | - | repeated dose toxicity | SCCS Opinion |
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Inserted via ATP: CLP00
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 0.1% | - | - | SCCP/0852/04 |
Expert safety assessment and concern-level summary for Bishydroxyethyl Biscetyl Malonamide.
Public NOAEL study rows linked to Bishydroxyethyl Biscetyl Malonamide by CAS number or substance name.
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.1% | SCCS PDF direct extraction | - |
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Bishydroxyethyl Biscetyl Malonamide has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: restricted. 4 toxicological study endpoint(s) are available in our database.
Bishydroxyethyl Biscetyl Malonamide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
Bishydroxyethyl Biscetyl Malonamide functions as: Skin conditioning agent (ceramide mimic / pseudo-ceramide); used in skin creams, shampoos, conditioners, makeup, sun care. It is classified as a cosmetic ingredient in our database. CAS number: 149591-38-8.
The NOAEL (No Observed Adverse Effect Level) for Bishydroxyethyl Biscetyl Malonamide is =15 mg/kg/day based on a repeated dose toxicity study via oral route in rat. A total of 4 study endpoints are available. Source: SCCS Opinion.
Bishydroxyethyl Biscetyl Malonamide also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Bishydroxyethyl Biscetyl Malonamide is prohibited in EU cosmetics but has active industrial GHS classifications (H319, H361f, H413).
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