Warning GHS08GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

N~1~,N~3~-Dihexadecyl-N~1~,N~3~-bis(2-hydroxyethyl)propanediamide

CAS 149591-38-8

N~1~,N~3~-Dihexadecyl-N~1~,N~3~-bis(2-hydroxyethyl)propanediamide (CAS 149591-38-8) is a chemical substance with GHS signal word Warning; key hazard signal: H361f ***; H319; H413. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Bishydroxyethyl Biscetyl Malonamide →

Cross-Vertical Regulatory Divergence

N~1~,N~3~-Dihexadecyl-N~1~,N~3~-bis(2-hydroxyethyl)propanediamide is prohibited in EU cosmetics but has active industrial GHS classifications (H361f, H319, H413).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 6 fields

Name

N~1~,N~3~-Dihexadecyl-N~1~,N~3~-bis(2-hydroxyethyl)propanediamide

CAS Number

149591-38-8

DTXSID

DTXSID60933683

Molecular Formula

C39H78N2O4

InChI Key

RHIIHYCQYFKTHL-UHFFFAOYSA-N

Monoisotopic Mass

638.596159

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Repr. 2; Eye Irrit. 2; Aquatic Chronic 4	H361f ***; H319; H413	GHS08; GHS07	Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records

HumectantSoftener and conditioner

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records

List	Keyword	Source
banned; Europe; Personal care	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 12 of 12 studies

Value	Unit	Endpoint	Route	Species	Source
913CU8H33E	UNII	FDA UNII substance identifier	-	-	openFDA substances
913CU8H33E	UNII	FDA UNII substance identifier	-	-	openFDA substances
913CU8H33E	UNII	FDA UNII substance identifier	-	-	openFDA substances
913CU8H33E	UNII	FDA UNII substance identifier	-	-	openFDA substances
150	mg/kg bw/day	LOAEL	oral	rat	COSMOS DB
15	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
=15	mg/kg/day	NOAEL	oral	-	SCCS Opinion
=15	mg/kg/day	NOAEL	oral	-	SCCS Opinion
=15	mg/kg/day	NOAEL	oral	-	SCCS Opinion
=15	mg/kg/day	NOAEL	oral	-	SCCS Opinion
15	mg/kg/day	repeated dose toxicity	oral	-	Regulatory source
15	mg/kg/day	repeated dose toxicity	oral	rat	Regulatory source

Showing 12 of 12 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	N,N'-dihexadecyl-N,N'-bis(2-hydroxyethyl)propanediamide	422-560-9	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed_with_terms

Conditions

Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Frequently Asked Questions

What is the GHS hazard classification for N~1~,N~3~-Dihexadecyl-N~1~,N~3~-bis(2-hydroxyethyl)propanediamide?

N~1~,N~3~-Dihexadecyl-N~1~,N~3~-bis(2-hydroxyethyl)propanediamide (CAS 149591-38-8) is classified under EU CLP Annex VI as Repr. 2; Eye Irrit. 2; Aquatic Chronic 4 with signal word Warning. Hazard statements: H361f ***; H319; H413. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for N~1~,N~3~-Dihexadecyl-N~1~,N~3~-bis(2-hydroxyethyl)propanediamide?

N~1~,N~3~-Dihexadecyl-N~1~,N~3~-bis(2-hydroxyethyl)propanediamide has 12 NOAEL studies in the database. The lowest reported value is 913CU8H33E UNII. Source: openFDA substances.

What regulatory lists include N~1~,N~3~-Dihexadecyl-N~1~,N~3~-bis(2-hydroxyethyl)propanediamide?

N~1~,N~3~-Dihexadecyl-N~1~,N~3~-bis(2-hydroxyethyl)propanediamide appears on 1 regulatory/inventory list including banned; Europe; Personal care. Source: EPA CPDat.

Is N~1~,N~3~-Dihexadecyl-N~1~,N~3~-bis(2-hydroxyethyl)propanediamide used in cosmetics?

Yes, N~1~,N~3~-Dihexadecyl-N~1~,N~3~-bis(2-hydroxyethyl)propanediamide is also indexed as a cosmetic ingredient under the name Bishydroxyethyl Biscetyl Malonamide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for N~1~,N~3~-Dihexadecyl-N~1~,N~3~-bis(2-hydroxyethyl)propanediamide come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does N~1~,N~3~-Dihexadecyl-N~1~,N~3~-bis(2-hydroxyethyl)propanediamide have different safety status in cosmetics vs industrial chemicals?

N~1~,N~3~-Dihexadecyl-N~1~,N~3~-bis(2-hydroxyethyl)propanediamide is prohibited in EU cosmetics but has active industrial GHS classifications (H361f, H319, H413).

Is N~1~,N~3~-Dihexadecyl-N~1~,N~3~-bis(2-hydroxyethyl)propanediamide used outside industrial chemicals?

N~1~,N~3~-Dihexadecyl-N~1~,N~3~-bis(2-hydroxyethyl)propanediamide also appears in cosmetics databases.