Is Betulin safe in cosmetics?
Betulin has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Betulin
Also known as: Trochol, NSC 4644, Lup-20(30)-ene-3beta,28-diol, Lup-20(29)-ene-3beta,28-diol, Lup-20(29)-ene-3,28-diol, (3beta)- (+13 more)
INCI: BETULIN
Betulin (CAS 473-98-3) is a cosmetic cosmetic ingredient functioning as Skin conditioning; anti-inflammatory, antioxidant, film-forming. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 473-98-3 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning; anti-inflammatory, antioxidant, film-forming
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA UNII: 6W70HN7X7O. Not specifically regulated for cosmetics; permitted under general safety provisions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Betulin.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
1 property record from structured ingredient metadata.
acne
{"cas_number": "473-98-3", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Betulin.
Known Synonyms
Trochol
NSC 4644
Lup-20(30)-ene-3beta,28-diol
Lup-20(29)-ene-3beta,28-diol
Lup-20(29)-ene-3,28-diol, (3beta)-
UNII-6W70HN7X7O
Betuline
AI3-62999
Betulinol
EINECS 207-475-5
Betulol
Lup-20(29)-ene-3,28-diol, (3β)-
(3β)-Lup-20(29)-ene-3,28-diol
3,28-Dihydroxy-lupeol
3β,28-Dihydroxylup-20(29)-ene
Betulinic alcohol
Lup-20(29)-ene-3β,28-diol
Lup-20(30)-ene-3β,28-diol
Chemical Function
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BETULIN
ChEMBL ID
CHEMBL23236
Frequently Asked Questions
Is Betulin allowed in the EU?
Betulin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Betulin do in cosmetics?
Betulin functions as: Skin conditioning; anti-inflammatory, antioxidant, film-forming. It is classified as a cosmetic ingredient in our database. CAS number: 473-98-3.
Is Betulin used outside cosmetics?
Betulin also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Betulin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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