Is Benzophenone-12 safe in cosmetics?
Benzophenone-12 has a safety rating of "GOOD" in our database. EU status: prohibited. US status: permitted.
Good
Cosmetic Ingredient
Benzophenone-12
Also known as: 2-Hydroxy-4-octyloxybenzophenone (Methanone, [2-hydroxy-4-(octyloxy)phenyl]phenyl-), Biosorb 130, BRN 1915198, EINECS 217-421-2, 2-Hydorxy-4-octoxybenzophenone (+7 more)
INCI: BENZOPHENONE-12
Benzophenone-12 (CAS 1843-05-6) is a cosmetic cosmetic ingredient functioning as UV absorber / light stabilizer. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1843-05-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Benzophenone-12 is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H412, H413).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
UV absorber / light stabilizer
Safety Rating
GOOD
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not an OTC sunscreen active; CIR concluded safe (2021). Also FDA-cleared as antioxidant/stabilizer in food-contact polymers at ≤0.5% (21 CFR 178.2010)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Benzophenone-12.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Benzophenone-12 across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Fragrance
Heat stabilizer
Stabilizing agent
UV stabilizer
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Benzophenone-12.
Regulatory Flags
ifra_fragrance
Known Synonyms
2-Hydroxy-4-octyloxybenzophenone (Methanone, [2-hydroxy-4-(octyloxy)phenyl]phenyl-)
Biosorb 130
BRN 1915198
EINECS 217-421-2
2-Hydorxy-4-octoxybenzophenone
2-Hydroxy-4-(n-octoxy)benzophenone
4-Octoxy-2-hydroxybenzophenone
2-Hydroxy-4-(octyloxy)benzophenon
2-Hydroxy-4-oktyloxybenzofenon
Octabenzonum
2-Hydroxy-4-octyloxybenzophenone
UNII-73P3618V2E
Chemical Function
UV stabilizer
Stabilizing agent
Fragrance
Regulatory Lists
Indirect additives food contact (10/2018)
drinking_water; Europe; manufacturing; plastic_additive
inert_ingredient; non_food_use; Pesticides
detected; Europe; Other indirect contact consumer goods
IFRA Transparency
pharmaceutical
Europe; plastic_additive
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
OCTABENZONE
ChEMBL ID
CHEMBL1977129
Max Phase
2
Frequently Asked Questions
Is Benzophenone-12 allowed in the EU?
Benzophenone-12 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Benzophenone-12 do in cosmetics?
Benzophenone-12 functions as: UV absorber / light stabilizer. It is classified as a cosmetic ingredient in our database. CAS number: 1843-05-6.
Is Benzophenone-12 used outside cosmetics?
Benzophenone-12 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Benzophenone-12 have different safety status in cosmetics vs industrial chemicals?
Benzophenone-12 is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H412, H413).
Compliance Tools
Check Benzophenone-12 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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