What is the NOAEL for Octabenzone?
Octabenzone has 9 NOAEL studies in the database. The lowest reported value is 6.61 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Octabenzone
Also known as: 2-Hydroxy-4-octyloxybenzophenone (Methanone, [2-hydroxy-4-(octyloxy)phenyl]phenyl-), Biosorb 130, BRN 1915198, EINECS 217-421-2, 2-Hydorxy-4-octoxybenzophenone (+7 more)
CAS 1843-05-6
Octabenzone (CAS 1843-05-6) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Octabenzone is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H412, H413).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Octabenzone
CAS Number
1843-05-6
DTXSID
DTXSID9027441
Molecular Formula
C21H26O3
InChI Key
QUAMTGJKVDWJEQ-UHFFFAOYSA-N
Monoisotopic Mass
326.188195
Synonyms
2-Hydroxy-4-octyloxybenzophenone (Methanone, [2-hydroxy-4-(octyloxy)phenyl]phenyl-)Biosorb 130BRN 1915198EINECS 217-421-22-Hydorxy-4-octoxybenzophenone2-Hydroxy-4-(n-octoxy)benzophenone4-Octoxy-2-hydroxybenzophenone2-Hydroxy-4-(octyloxy)benzophenon2-Hydroxy-4-oktyloxybenzofenonOctabenzonum2-Hydroxy-4-octyloxybenzophenoneUNII-73P3618V2E
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
UV stabilizerStabilizing agentFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| detected; Europe; Other indirect contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| pharmaceutical | US International Trade Commission | CPCat |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| Europe | European Chemicals Agency | European Chemicals Agency (ECHA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 807 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =6.61 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 73P3618V2E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 73P3618V2E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 73P3618V2E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 73P3618V2E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1.37e-8 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| >10000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Octabenzone | 217-421-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
OCTABENZONE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include Octabenzone?
Octabenzone appears on 8 regulatory/inventory lists including Indirect additives food contact (10/2018), drinking_water; Europe; manufacturing; plastic_additive, inert_ingredient; non_food_use; Pesticides, and 5 more. Source: EPA CPDat.
Is Octabenzone used in cosmetics?
Yes, Octabenzone is also indexed as a cosmetic ingredient under the name Benzophenone-12. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Octabenzone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Octabenzone have different safety status in cosmetics vs industrial chemicals?
Octabenzone is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H412, H413).
Is Octabenzone used outside industrial chemicals?
Octabenzone also appears in cosmetics, pharmaceutical databases.