Is Basic Red 76 safe in cosmetics?
Basic Red 76 has a safety rating of "GOOD" in our database. EU status: prohibited. US status: permitted. 8 toxicological study endpoint(s) are available in our database.
Basic Red 76
Also known as: 2-Naphthalenaminium, 7-hydroxy-8-[2-(2-methoxyphenyl)diazenyl]-N,N,N-trimethyl-, chloride (1:1), 2-Naphthalenaminium, 7-hydroxy-8-((2-methoxyphenyl)azo)-N,N,N-trimethyl-, chloride, C.I.12245, (7-Hydroxy-8-((2-methoxyphenyl)azo)-2-naphthyl)trimethylammonium chloride
Basic Red 76 (CAS 68391-30-0) is a cosmetic cosmetic ingredient functioning as Dye. Reported NOAEL =200 mg/kg bw/day in rat (SCCNFP_vision_codex); EU Regulation 1223/2009 status: prohibited, max 2.0%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 68391-30-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Basic Red 76 is prohibited in EU cosmetics at max 2.0% but has active industrial GHS classifications (H400, H410).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Regulatory Status
EU EU Status
prohibited
EU Max Conc.
2.0%
US US Status
permitted
US Notes
Not an FDA-approved color additive; coal tar hair dye exemption applies for hair dye use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Basic Red 76.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Basic Red 76. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =200 mg/kg bw/day | oral | rat | NOAEL study | SCCNFP_vision_codex |
| NOAEL | =200 mg/kg bw/day | oral | rat | NOAEL study | SCCNFP_vision_codex |
| NOAEL | =200 mg/kg bw/day | oral | rat | NOAEL study | SCCNFP_vision_codex |
| NOAEL | =200 mg/kg bw/day | oral | rat | NOAEL study | SCCNFP_vision_codex |
| NOAEL | =60 mg/kg bw/day | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =60 mg/kg bw/day | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =60 mg/kg bw/day | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =60 mg/kg bw/day | - | - | NOAEL study | SCCS_vision_codex |
Sensitization Profile
Contact sensitization data for Basic Red 76 based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.2%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis
Source: IVDK; NACDG; ESSCA
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance non-oxidative hair dye products. Max: 2,0 %.
JPKR Japan/Korea Cosmetics
Korea (Restricted): max 2.0%
BRIN Brazil/India Cosmetics
India: Restricted · max 2,0 %
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_hair_dye | 2 | Non-oxidative hair dye (direct) |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
EPA Dryad Skin Absorption (physics-based)
MW: 371.861
LogP: 1.9105
Kp epidermis: 0.00169 cm/h
% dose epidermis: 0.95%
% dose stratum corneum: 0.94%
% dose dermis: 0.92%
Source: EPA_Dryad_Skin_Absorption_2024
Roberts Skin Permeation (Mendeley 2022)
MW: 371.86
Log Kow: -1.78
Log Kp: -2.7717418724660194
Log Jmax: -9.032624506281845
Source: Roberts_Cheruvu_Mendeley_2022
Additional Ingredient Properties
2 property records from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "dye", "cross_reactivity_group": "para-amino-group", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "IVDK; NACDG; ESSCA"}
hair_dye
{"cas_number": "68391-30-0", "ingredient_class": "direct_dye", "color_index_CI_number": "12245", "chemical_class": "azo", "color_result_on_hair": "Red", "shade_range": "red", "primary_function": "direct_deposit", "requires_developer": "no", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "8-15", "light_fastness": "moderate", "oxidation_mechanism": "direct_absorptio…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Basic Red 76.
Regulatory Flags
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Basic Red 76 by CAS number or substance name.
Studies
8
Lowest NOAEL
60 mg/kg bw/day
Highest NOAEL
200 mg/kg bw/day
SCCS_vision_codex
SCCNFP_vision_codex
Known Synonyms
2-Naphthalenaminium, 7-hydroxy-8-[2-(2-methoxyphenyl)diazenyl]-N,N,N-trimethyl-, chloride (1:1)
2-Naphthalenaminium, 7-hydroxy-8-((2-methoxyphenyl)azo)-N,N,N-trimethyl-, chloride
C.I.12245
(7-Hydroxy-8-((2-methoxyphenyl)azo)-2-naphthyl)trimethylammonium chloride
Chemical Function
Dye
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Basic Red 76 allowed in the EU?
Basic Red 76 EU regulatory status: prohibited. Maximum allowed concentration: 2.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does Basic Red 76 do in cosmetics?
Basic Red 76 functions as: Dye. It is classified as a cosmetic ingredient in our database. CAS number: 68391-30-0.
What is the NOAEL for Basic Red 76?
The NOAEL (No Observed Adverse Effect Level) for Basic Red 76 is =200 mg/kg bw/day based on a NOAEL study study via oral route in rat. A total of 8 study endpoints are available. Source: SCCNFP_vision_codex.
Is Basic Red 76 used outside cosmetics?
Basic Red 76 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Basic Red 76 have different safety status in cosmetics vs industrial chemicals?
Basic Red 76 is prohibited in EU cosmetics at max 2.0% but has active industrial GHS classifications (H400, H410).
Compliance Tools
Check Basic Red 76 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acid Blue 9
Excellent
Same category
Colorant, Hair Dyeing
Acid Blue 9 Aluminum Lake
Excellent
Same category
Colorant
Anthocyanins
Excellent
Same category
Colorant
Beta Vulgaris Extract
Excellent
Same category
Skin Conditioning, Colorant (betalain...
Beta Vulgaris Root Extract
Excellent
Same category
Skin Conditioning, Colorant (betanin/...
Beta Vulgaris Root Powder
Excellent
Same category
Skin conditioning, natural colorant, ...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
Basic Yellow 57
Good
Chemical family
Hair dyeing (semi-permanent cationic ...
Di-C12-18 Alkyl Dimonium Chloride
Moderate
Chemical family
Hair conditioning, skin conditioning ...
Di-C14-18 Alkyl Dimonium Chloride
Moderate
Chemical family
Hair conditioning agent; skin conditi...
Is Basic Red 76 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Basic Red 76 in your formulation.