What is the NOAEL for C.I. Basic Red 76?
C.I. Basic Red 76 has 30 NOAEL studies in the database. The lowest reported value is 60 mg/kg bw/day. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.
NOAEL Data
REACH Registered
Cosmetic Ingredient
C.I. Basic Red 76
Also known as: 2-Naphthalenaminium, 7-hydroxy-8-[2-(2-methoxyphenyl)diazenyl]-N,N,N-trimethyl-, chloride (1:1), 2-Naphthalenaminium, 7-hydroxy-8-((2-methoxyphenyl)azo)-N,N,N-trimethyl-, chloride, Basic Red 76, C.I.12245, (7-Hydroxy-8-((2-methoxyphenyl)azo)-2-naphthyl)trimethylammonium chloride
CAS 68391-30-0
C.I. Basic Red 76 (CAS 68391-30-0) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
Cross-Vertical Regulatory Divergence
C.I. Basic Red 76 is prohibited in EU cosmetics at max 2.0% but has active industrial GHS classifications (H400, H410).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
30
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
C.I. Basic Red 76
CAS Number
68391-30-0
DTXSID
DTXSID10879784
Molecular Formula
C20H21N3O2.ClH
InChI Key
HSWXSHNPRUMJKI-UHFFFAOYSA-N
Monoisotopic Mass
371.140055
Synonyms
2-Naphthalenaminium, 7-hydroxy-8-[2-(2-methoxyphenyl)diazenyl]-N,N,N-trimethyl-, chloride (1:1)2-Naphthalenaminium, 7-hydroxy-8-((2-methoxyphenyl)azo)-N,N,N-trimethyl-, chlorideBasic Red 76C.I.12245(7-Hydroxy-8-((2-methoxyphenyl)azo)-2-naphthyl)trimethylammonium chloride
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 30 of 30 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 60 | mg/kg bw/day | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 60 | mg/kg bw/day | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 200 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCNFP:beta.noael_studies |
| ES19W9WI76 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ES19W9WI76 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ES19W9WI76 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ES19W9WI76 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 60 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| =60 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =60 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =60 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| =60 | mg/kg bw/day | NOAEL | - | - | SCCS_vision_codex |
| >98 | % | NOAEL | dermal | mouse | SCCNFP_vision_codex |
| >98 | % | NOAEL | dermal | mouse | SCCNFP_vision_codex |
| >98 | % | NOAEL | dermal | mouse | SCCNFP_vision_codex |
| >98 | % | NOAEL | dermal | mouse | SCCNFP_vision_codex |
| =200 | mg/kg bw/day | NOAEL | oral | rat | SCCNFP_vision_codex |
| =200 | mg/kg bw/day | NOAEL | oral | rat | SCCNFP_vision_codex |
| =200 | mg/kg bw/day | NOAEL | oral | rat | SCCNFP_vision_codex |
| =200 | mg/kg bw/day | NOAEL | oral | rat | SCCNFP_vision_codex |
| >98 | % | carcinogenicity | dermal | mouse | UnifiedCodex:SCCNFP:beta.noael_studies |
| >98 | % | carcinogenicity | dermal | human | UnifiedCodex:SCCNFP:beta.noael_studies |
| >98 | % | carcinogenicity | dermal | human | UnifiedCodex:SCCNFP:beta.noael_studies |
| 60 | mg/kg bw/day | developmental toxicity | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 60 | mg/kg bw/day | developmental toxicity | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 60 | mg/kg bw/day | developmental toxicity | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 60 | mg/kg bw/day | developmental toxicity | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 60 | mg/kg bw/day | genotoxicity | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 60 | mg/kg bw/day | genotoxicity | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 60 | mg/kg bw/day | repeated dose toxicity | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
Showing 30 of 30 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | [7-hydroxy-8-[(2-methoxyphenyl)azo]-2-naphthyl]trimethylammonium chloride | 269-941-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1421/11 | 21 June 2011 | safe | 2.0% | sensitisation potential; secondary amine; nitrosamine <50ppb |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
2.0%
Category
Colorant
Frequently Asked Questions
What regulatory lists include C.I. Basic Red 76?
C.I. Basic Red 76 appears on 3 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), Europe; Personal care - hair coloring, Europe; Personal care; restricted. Source: EPA CPDat.
Is C.I. Basic Red 76 used in cosmetics?
Yes, C.I. Basic Red 76 is also indexed as a cosmetic ingredient under the name Basic Red 76. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for C.I. Basic Red 76 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does C.I. Basic Red 76 have different safety status in cosmetics vs industrial chemicals?
C.I. Basic Red 76 is prohibited in EU cosmetics at max 2.0% but has active industrial GHS classifications (H400, H410).
Is C.I. Basic Red 76 used outside industrial chemicals?
C.I. Basic Red 76 also appears in cosmetics databases.