NOAEL Studies Cosmetic Ingredient

Barium Sulfate NOAEL Studies

INCI: BARIUM SULFATE

CAS: 7727-43-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL =40 mg/m3 Rat inhalation subchronic; 2 months subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15235/7/6/3?documentUUID=08b1909a-7a8c-47c7-b438-33a20d59aef1; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID:15827959:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f2d076dcb4ddc14497e7397b75aa9722
ToxValDB_ECHA_IUCLID LEL >=250 mg/m3 Rat inhalation chronic; 6 months chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15235/7/6/3?documentUUID=08b1909a-7a8c-47c7-b438-33a20d59aef1; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829637_15829638:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0b059bb437ddf3e33c0cce2cf164b4dc
ToxValDB_ECHA_IUCLID LEL <=300 mg/m3 Rat inhalation chronic; 6 months chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15235/7/6/3?documentUUID=08b1909a-7a8c-47c7-b438-33a20d59aef1; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829637_15829638:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6d686de1f0d903b508e6df452419a31d
ToxValDB_ECHA_IUCLID NOAEL =4000 ppm Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab5ae4b0a7c65d1b9e94; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15235/7/9/2?documentUUID=08b1909a-7a8c-47c7-b438-33a20d59aef1; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID:15855616:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_32512f112451541a3f38aa45a62b147a
ToxValDB_ECHA_IUCLID NOAEL =201.5 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab5ae4b0a7c65d1b9e94; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15235/7/9/2?documentUUID=08b1909a-7a8c-47c7-b438-33a20d59aef1; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID:15856400:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7f5cde91700b20b1b1409b55cd188f95
ToxValDB_ECHA_IUCLID NOAEL =179.5 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab5ae4b0a7c65d1b9e94; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15235/7/9/2?documentUUID=08b1909a-7a8c-47c7-b438-33a20d59aef1; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID:15856779:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7973ff00b551ffd822216665138ddaef
ToxValDB_ECHA_IUCLID NOAEL =2000 ppm Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c94fe4b0a7c65d21c5bc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15235/7/9/2?documentUUID=08b1909a-7a8c-47c7-b438-33a20d59aef1; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID:15857727:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1b10d7a8bc034d17b4c6f96e825139c3
ToxValDB_EPA_TSCA_8e 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EPA_TSCA_8e NEL =50 mg/m3 Rat oral chronic; 2 years chronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-16-20448_369726.pdf; TOXICOLOGICAL_EFFECT=no body weight changes, no mortality difference from control, no macroscopic tumors detected; STUDY_GROUP=EPA TSCA 8e:15957017:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d643003f2222795aa33a2c2ba1d75a19
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL local =10 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15629938_15629939:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_12a92a3938a4900c9d9e7f5a082680b7
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 25BB7EKE2E UNII - - - chemical {"approval_status":null,"molecular_formula":"Ba.O4S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"25BB7EKE2E"}
openFDA substances FDA UNII substance identifier 25BB7EKE2E UNII - - - chemical {"approval_status":null,"molecular_formula":"Ba.O4S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"25BB7EKE2E"}
openFDA substances FDA UNII substance identifier 25BB7EKE2E UNII - - - chemical {"approval_status":null,"molecular_formula":"Ba.O4S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"25BB7EKE2E"}
openFDA substances FDA UNII substance identifier 25BB7EKE2E UNII - - - chemical {"approval_status":null,"molecular_formula":"Ba.O4S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"25BB7EKE2E"}