Is Asiaticoside safe in cosmetics?
Asiaticoside has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Asiaticoside
INCI: ASIATICOSIDE
Asiaticoside (CAS 16830-15-2) is a cosmetic active ingredient functioning as anti-inflammatory, wound-healing, barrier-repair. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 16830-15-2 →
Auto-generated CPSR Part A draft with source citations
Function
anti-inflammatory, wound-healing, barrier-repair
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; no US concentration cap. Co-active with madecassoside in Centella asiatica triterpene extract. Used at 0.1–1% in leave-on formulations.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Asiaticoside.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Asiaticoside, relevant to systemic exposure and MoS calculations.
Absorption %
0.5-2%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
959.1 Da
Log P
-2.2
Systemic Absorption
minimal
Topical Bioavailability
0.2-1%
Safety Margin Factor
minimal
Vehicle Dependent
Yes — absorption varies by formulation
Source: Phytomedicine 2010
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "16830-15-2", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction…
anti_aging
{"anti_aging_claim": "collagen-boosting, barrier-repair", "mechanism_of_action": "Bioactive compound, specialized mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Yes", "elastin_protection": "Mild", "wrinkle_reduction_pct": "15-25", "clinical_study_duration_weeks": "12", "sample_size": "35", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JAA…
anti_pollution
{"cas_number": "16830-15-2", "ingredient_class": "antioxidant_pollution_shield", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,sensitive,combination,normal,rosacea", "acne_safe": "yes", "source": "Centella derivative"}
concentration
{"min_concentration_pct": "0.1", "max_concentration_pct": "1.0", "typical_concentration_pct": "0.5", "product_type": "Scar Treatment", "function_at_concentration": "Wound healing", "source": "Clinical literature"}
depigmentation
{"cas_number": "16830-15-2", "ingredient_class": "anti_inflammatory_brightener", "primary_mechanism_of_action": "Centella asiatica glycoside reducing PIH", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_clinical": "15-30", "onse…
dermal_absorption
{"molecular_weight_da": "959.1", "log_p_value": "-2.2", "skin_penetration_level": "surface", "penetration_depth": "stratum corneum", "absorption_pct": "0.5-2", "systemic_absorption": "minimal", "penetration_enhancer": "no", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "strengthens", "bioavailability_topical_pct": "0.2-1", "safety_margin_factor": "minimal", "source":…
pediatric_safety
{"safe_for_newborn_0_6m": "yes", "safe_for_infant_6_12m": "yes", "safe_for_toddler_1_3y": "yes", "safe_for_child_3_12y": "yes", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "2.0", "adult_max_concentration_pct": "2.0", "pediatric_dermal_absorption_factor": "normal", "diaper_area_safe": "yes", "pediatric_allergy_prevalence": "low", "banned_in_children_products_eu": "no", "banned…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Fragrance
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Asiaticoside.
Regulatory Flags
active
wound-healing
anti-inflammatory
barrier-repair
collagen-stimulator
filaggrin-booster
involucrin-booster
nf-kb-inhibitor
centella-asiatica
botanical
atopic-dermatitis-target
sensitive-skin
Chemical Function
Antioxidant
Softener and conditioner
Fragrance
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1684590
Frequently Asked Questions
Is Asiaticoside allowed in the EU?
Asiaticoside EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Asiaticoside do in cosmetics?
Asiaticoside functions as: anti-inflammatory, wound-healing, barrier-repair. It is classified as a Active Ingredient in our database. CAS number: 16830-15-2.
Is Asiaticoside used outside cosmetics?
Asiaticoside also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Asiaticoside compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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ASPARAGOPSIS ARMATA EXTRACT
Good
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ASPARAGUS OFFICINALIS EXTRACT
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ASPERGILLUS/APRICOT KERNEL/ARTEMISIA ANNUA/AQUILARIA AGALLOCHA STEM/ELETTARIA CARDAMOMUM SEED/CORDYCEPS SINENSIS/HERICIUM ERINACEUM/POLYPORUS UMBELLATUS/WHEAT FLOUR/XANTHIUM STRUMARIUM FRUIT FERMENT EXTRACT FILTRATE
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