Is Artemisinin safe in cosmetics?
Artemisinin has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Artemisinin
Also known as: 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,12S,12aR)-, 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, [3R-(3α,5aβ,6β,8aβ,9α,12β,12aR*)]-, (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, Artemisia annua L., extract, Artemisine (+14 more)
INCI: ARTEMISININ
Artemisinin (CAS 63968-64-9) is a cosmetic cosmetic ingredient functioning as Antimicrobial, Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 63968-64-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Artemisinin is classified GHS Danger (H242, H400, H410) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antimicrobial, Skin Conditioning
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically restricted by FDA for cosmetics; no color additive listing needed. Known primarily as an antimalarial drug (FDA-approved pharmaceutical); cosmetic use is self-regulated under MoCRA
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Artemisinin.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Artemisinin.
Known Synonyms
3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,12S,12aR)-
3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, [3R-(3α,5aβ,6β,8aβ,9α,12β,12aR*)]-
(3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
Artemisia annua L., extract
Artemisine
BRN 4194670
Qing Hau SU
Qinghosu
NSC 369397
Artemisininum
Qing Hau Sau
UNII-9RMU91N5K2
1,5,9-trimethyl-(1R,4S,5R,9R,12S,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one
Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10(3H)-one
QHS
Qinghaosu
arteannuin
artemisinina
artemisinine
Chemical Function
Biocide
Softener and conditioner
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ARTEMISININ
ChEMBL ID
CHEMBL269671
Max Phase
3
Frequently Asked Questions
Is Artemisinin allowed in the EU?
Artemisinin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Artemisinin do in cosmetics?
Artemisinin functions as: Antimicrobial, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 63968-64-9.
Is Artemisinin used outside cosmetics?
Artemisinin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Artemisinin have different safety status in cosmetics vs industrial chemicals?
Artemisinin is classified GHS Danger (H242, H400, H410) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Artemisinin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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