What is the NOAEL for Artemisinin?
Artemisinin has 5 NOAEL studies in the database. The lowest reported value is 9RMU91N5K2 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Artemisinin
Also known as: 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,12S,12aR)-, 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, [3R-(3α,5aβ,6β,8aβ,9α,12β,12aR*)]-, (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, Artemisia annua L., extract, Artemisine (+14 more)
CAS 63968-64-9
Artemisinin (CAS 63968-64-9) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
Cross-Vertical Regulatory Divergence
Artemisinin is classified GHS Danger (H242, H400, H410) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Artemisinin
CAS Number
63968-64-9
DTXSID
DTXSID2040652
Molecular Formula
C15H22O5
InChI Key
BLUAFEHZUWYNDE-NNWCWBAJSA-N
Monoisotopic Mass
282.146724
Synonyms
3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,12S,12aR)-3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, [3R-(3α,5aβ,6β,8aβ,9α,12β,12aR*)]-(3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-oneArtemisia annua L., extractArtemisineBRN 4194670Qing Hau SUQinghosuNSC 369397ArtemisininumQing Hau SauUNII-9RMU91N5K2
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
BiocideSoftener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 9RMU91N5K2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9RMU91N5K2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9RMU91N5K2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9RMU91N5K2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =5576 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | (3R,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10(3H)-one | 700-290-5 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ARTEMISININ
ChEMBL Phase
3
Adverse Events
0
Bioactivity
15
Frequently Asked Questions
What regulatory lists include Artemisinin?
Artemisinin appears on 2 regulatory/inventory lists including pharmaceutical, Canada; pharmaceutical. Source: EPA CPDat.
Is Artemisinin used in cosmetics?
Yes, Artemisinin is also indexed as a cosmetic ingredient under the name Artemisinin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Artemisinin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Artemisinin have different safety status in cosmetics vs industrial chemicals?
Artemisinin is classified GHS Danger (H242, H400, H410) in the chemicals database but is allowed in EU cosmetics.
Is Artemisinin used outside industrial chemicals?
Artemisinin also appears in cosmetics, pharmaceutical databases.