Is Andrographolide safe in cosmetics?
Andrographolide has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Andrographolide
Also known as: EINECS 226-852-5, NSC 383468, UNII-410105JHGR, (1R-(1-alpha(E(S)),4abeta,5alpha,6alpha,8aalpha))-3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-2(3H)-furanone, 3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphthyl)ethylidene)dihydro-4-hydroxyfuran-2(3H)-one (+1 more)
INCI: ANDROGRAPHOLIDE
Andrographolide (CAS 5508-58-7) is a cosmetic cosmetic ingredient functioning as skin conditioning, anti-inflammatory, antioxidant, antimicrobial. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 5508-58-7 →
Auto-generated CPSR Part A draft with source citations
Function
skin conditioning, anti-inflammatory, antioxidant, antimicrobial
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one
InChIKey
BOJKULTULYSRAS-OTESTREVSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA restrictions for topical use; used in anti-aging and soothing formulations
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Andrographolide.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Andrographolide.
Regulatory Flags
active_compound
anti_inflammatory
antioxidant
skin_soothing
natural_diterpene
Known Synonyms
EINECS 226-852-5
NSC 383468
UNII-410105JHGR
(1R-(1-alpha(E(S)),4abeta,5alpha,6alpha,8aalpha))-3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-2(3H)-furanone
3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphthyl)ethylidene)dihydro-4-hydroxyfuran-2(3H)-one
3alpha,14,15,18-tetrahydroxy-5b,9bH,10a-labda-8(20),12-dien-16-oic acid gamma-Lactone
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ANDROGRAPHOLIDE
ChEMBL ID
CHEMBL186141
Max Phase
3
Frequently Asked Questions
Is Andrographolide allowed in the EU?
Andrographolide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Andrographolide do in cosmetics?
Andrographolide functions as: skin conditioning, anti-inflammatory, antioxidant, antimicrobial. It is classified as a cosmetic ingredient in our database. CAS number: 5508-58-7.
Is Andrographolide used outside cosmetics?
Andrographolide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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