What is the NOAEL for Andrographolide?
Andrographolide has 4 NOAEL studies in the database. The lowest reported value is 410105JHGR UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Andrographolide
Also known as: EINECS 226-852-5, NSC 383468, UNII-410105JHGR, (1R-(1-alpha(E(S)),4abeta,5alpha,6alpha,8aalpha))-3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-2(3H)-furanone, 3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphthyl)ethylidene)dihydro-4-hydroxyfuran-2(3H)-one (+1 more)
CAS 5508-58-7
Andrographolide (CAS 5508-58-7) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
Andrographolide
CAS Number
5508-58-7
DTXSID
DTXSID3045980
Molecular Formula
C20H30O5
InChI Key
BOJKULTULYSRAS-OTESTREVSA-N
Monoisotopic Mass
350.209324
Synonyms
EINECS 226-852-5NSC 383468UNII-410105JHGR(1R-(1-alpha(E(S)),4abeta,5alpha,6alpha,8aalpha))-3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-2(3H)-furanone3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphthyl)ethylidene)dihydro-4-hydroxyfuran-2(3H)-one3alpha,14,15,18-tetrahydroxy-5b,9bH,10a-labda-8(20),12-dien-16-oic acid gamma-Lactone
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Softener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 410105JHGR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 410105JHGR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 410105JHGR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 410105JHGR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Plant Extract
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ANDROGRAPHOLIDE
ChEMBL Phase
3
Adverse Events
0
Bioactivity
6
Frequently Asked Questions
What regulatory lists include Andrographolide?
Andrographolide appears on 1 regulatory/inventory list including Canada; pharmaceutical. Source: EPA CPDat.
Is Andrographolide used in cosmetics?
Yes, Andrographolide is also indexed as a cosmetic ingredient under the name Andrographolide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Andrographolide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Andrographolide used outside industrial chemicals?
Andrographolide also appears in cosmetics, pharmaceutical databases.