NOAEL Studies Cosmetic Ingredient

Aminoethylethanolamine NOAEL Studies

INCI: AMINOETHYLETHANOLAMINE

CAS: 111-41-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =3000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1033; row=11965; data_type=In Vivo; mixture=Chemical; chemical_name=N-(Hydroxyethyl)ethylenediamine; preferred_name=N-(Hydroxyethyl)ethylenediamine; dtxsid=DTXSID7025423; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025423; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7025423; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization EC3 15.2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13343; Record_ID=skin_sensitization_invivo_3459; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7025423; Assay=LLNA; Endpoint=EC3; Response=15.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=BASF personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025423; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025423
NTP_ICE_skin_sensitization EC3 15.2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13343; Record_ID=skin_sensitization_invivo_3459; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7025423; Assay=LLNA; Endpoint=EC3; Response=15.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=BASF personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025423; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025423
NTP_ICE_skin_sensitization EC3 15.2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13343; Record_ID=skin_sensitization_invivo_3459; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7025423; Assay=LLNA; Endpoint=EC3; Response=15.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=BASF personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025423; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025423
NTP_ICE_skin_sensitization EC3 15.2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13343; Record_ID=skin_sensitization_invivo_3459; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7025423; Assay=LLNA; Endpoint=EC3; Response=15.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=BASF personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025423; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025423
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Protective_Action_Criteria LEL =42598.6 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=DOE Protective Action Criteria:15512054:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6c46f4b2f85c945ed31bb6eb3a49b310
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =0.2 mg/kg bw/day Rat oral - developmental GUIDELINE=other:; QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb7d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14787/7/9/3?documentUUID=8392ae51-ac84-47ad-99b5-5dd16bce73e7; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15824064:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2fb3e6aebd3479e04180f66168e63400
ToxValDB_ECHA_IUCLID LOEL =50 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa64e4b0a7c65d1b598b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14787/7/9/2?documentUUID=8392ae51-ac84-47ad-99b5-5dd16bce73e7; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15862292:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4f6b9cd3937b0d38595543c8e8b61d2c
ToxValDB_ECHA_IUCLID NOAEL =50 mg/kg bw/day Rat oral - reproduction developmental GUIDELINE=other:; QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb7d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14787/7/9/3?documentUUID=8392ae51-ac84-47ad-99b5-5dd16bce73e7; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15824065_15824066:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_365dc91cc871c41d6dd73c005a4dddd5
ToxValDB_ECHA_IUCLID NOAEL =250 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa64e4b0a7c65d1b598b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14787/7/9/2?documentUUID=8392ae51-ac84-47ad-99b5-5dd16bce73e7; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15861270_15862072:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cdc5b530b85c0f011e0ee9da6a221b29
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =0.704 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629746:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_236c0138581d06f507bc66f7a03d7811
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier RC78W6NPXT UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H12N2O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RC78W6NPXT"}
openFDA substances FDA UNII substance identifier RC78W6NPXT UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H12N2O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RC78W6NPXT"}
openFDA substances FDA UNII substance identifier RC78W6NPXT UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H12N2O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RC78W6NPXT"}
openFDA substances FDA UNII substance identifier RC78W6NPXT UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H12N2O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RC78W6NPXT"}