Is Aloe Barbadensis Leaf Juice safe in cosmetics?
Aloe Barbadensis Leaf Juice has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Aloe Barbadensis Leaf Juice
Also known as: Aloe extract, OILS, ALOE VERA, EINECS No.: 287-390-8
INCI: ALOE BARBADENSIS LEAF JUICE
Aloe Barbadensis Leaf Juice (CAS 85507-69-3) is a cosmetic active ingredient functioning as Skin-conditioning, humectant, soothing, wound healing support. Acemannan. EU Regulation 1223/2009 status: permitted, max No concentration limit for inner leaf gel/juice; whole-leaf extract requires specification controls (aloe-emodin anthraquinone avoidance). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 85507-69-3 →
Auto-generated CPSR Part A draft with source citations
Function
Skin-conditioning, humectant, soothing, wound healing support. Acemannan (acetylated mannose polysaccharide) is the primary wound-active constituent: modulates macrophage activity, promotes fibroblast proliferation and ECM synthesis, reduces pro-inflammatory cytokines.
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
EU Max Conc.
No concentration limit for inner leaf gel/juice; whole-leaf extract requires specification controls (aloe-emodin anthraquinone avoidance)
US US Status
permitted
US Notes
No FDA limits for cosmetic use. Inner leaf gel specification recommended. Anti-inflammatory soothing humectant for skin hydration.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Aloe Barbadensis Leaf Juice.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Aloe Barbadensis Leaf Juice based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
botanical
EU Allergen Listed
no
Patch Test Positive Rate
0.5%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
Source: IVDK; ESSCA; NACDG
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Face Cream | 1–10 | 80 | CIR/VCRP |
| Toner | 20–80 | 80 | CIR/VCRP |
| Sunscreen | 2–10 | 15 | CIR/VCRP |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "85507-69-3", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restrictio…
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "botanical", "patch_test_frequency_pct": "0.5", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "IVDK; ESSCA; NACDG"}
anti_pollution
{"cas_number": "85507-69-3", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5/UV_A", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_in…
baby_pediatric
{"cas_number": "85507-69-3", "ingredient_class": "moisturizer_baby", "pediatric_safety_rating": "good", "minimum_age_months": "0", "neonatal_safe": "yes", "premature_infant_safe": "yes", "skin_barrier_maturity_consideration": "Soothing, hydrating; verify aloin-free (laxative component)", "transepidermal_absorption_risk_pediatric": "low", "dose_per_kg_body_weight_concern": "Topical hydration", "ski…
concentration
{"min_concentration_pct": "1.0", "max_concentration_pct": "10.0", "typical_concentration_pct": "5.0", "product_type": "After-Sun", "function_at_concentration": "Soothing, cooling", "source": "Supplier TDS"}
pregnancy_detail
{"pregnancy_safe": "yes", "breastfeeding_safe": "yes", "risk_category": "not-rated", "reason": "Safe topically; soothing", "source": "ACOG; dermatology literature"}
self_tanning
{"cas_number": "85507-69-3", "ingredient_class": "tan_extender", "tanning_mechanism": "other", "color_development_onset_hours": "0.0", "full_color_development_hours": "0", "color_duration_days": "3", "DHA_concentration_if_applicable_pct": "0", "erythrulose_concentration_pct": "0", "pH_dependent_color": "no", "skin_pH_interaction": "moisturizes to extend tan", "formaldehyde_release_concern": "no", …
sensory
{"silky": "gel-like", "smooth, glides easily": "cool, soothing", "dry-touch, non-greasy": "hydrated, fresh", "instant": "moderate", "low": "medium", "w/o": "o/w", "very-high": "moderate", "no": "no", "yes": "no", "1.40": "1.34", "transparent": "transparent", "colorless": "colorless", "excellent": "fair", "light": "light", "synthetic": "botanical"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
No specific technical function
Softener and conditioner
Regulatory List Membership (2)
EU Regulated in Personal Care
EPA Safer Chemical Ingredients List (SCIL)
Expert Verdict
Expert safety assessment and concern-level summary for Aloe Barbadensis Leaf Juice.
Regulatory Flags
active-wound-healing
acemannan-active
anti-inflammatory
cochrane-mixed-evidence
anthraquinone-risk
phototoxic-if-unpurified
purity-documentation-required
claims-sensitive
split-graft-evidence
eu_children_restricted
epa_safer_alternative
Known Synonyms
Aloe extract
OILS, ALOE VERA
EINECS No.: 287-390-8
Chemical Function
Softener and conditioner
Humectant
Regulatory Lists
Europe; Personal care
Europe; Personal care
Europe; Personal care
SCIL (9/2019)
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Aloe Barbadensis Leaf Juice allowed in the EU?
Aloe Barbadensis Leaf Juice EU regulatory status: permitted. Maximum allowed concentration: No concentration limit for inner leaf gel/juice; whole-leaf extract requires specification controls (aloe-emodin anthraquinone avoidance). This is based on EU Regulation 1223/2009 and its amendments.
What does Aloe Barbadensis Leaf Juice do in cosmetics?
Aloe Barbadensis Leaf Juice functions as: Skin-conditioning, humectant, soothing, wound healing support. Acemannan (acetylated mannose polysaccharide) is the primary wound-active constituent: modulates macrophage activity, promotes fibroblast proliferation and ECM synthesis, reduces pro-inflammatory cytokines.. It is classified as a Active Ingredient in our database. CAS number: 85507-69-3.
Is Aloe Barbadensis Leaf Juice used outside cosmetics?
Aloe Barbadensis Leaf Juice also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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