NOAEL Studies Cosmetic Ingredient

Acid Red 87 NOAEL Studies

INCI: CI 45380

CAS: 17372-87-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 0 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=233; Record_ID=adme_parameters_1005; Data_Type=Measured; DTXSID=DTXSID0025234; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=0.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025234; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025234
NTP_ICE_adme_parameters Fu 0.0524 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=234; Record_ID=adme_parameters_1005; Data_Type=Measured; DTXSID=DTXSID0025234; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0524; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025234; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025234
NTP_ICE_endocrine 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50 22.10533985 uM - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=8844; RecordID=ARPathway2016_90; DatasetName=ARPathway2016; DTXSID=DTXSID0025234; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=22.10533985; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025234; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025234
NTP_ICE_endocrine ACC 27.90394502 uM - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=8845; RecordID=ARPathway2016_90; DatasetName=ARPathway2016; DTXSID=DTXSID0025234; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=27.90394502; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025234; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025234
NTP_ICE_endocrine Model Score 0.169 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=8846; RecordID=ARPathway2016_90; DatasetName=ARPathway2016; DTXSID=DTXSID0025234; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.169; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025234; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025234
NTP_ICE_endocrine Model Score 0.0465 unitless - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=8847; RecordID=ARPathway2016_90; DatasetName=ARPathway2016; DTXSID=DTXSID0025234; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0.0465; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025234; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025234
NTP_ICE_endocrine Model Score 0 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=8850; RecordID=ERPathway2016_606; DatasetName=ERPathway2016; DTXSID=DTXSID0025234; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025234; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025234
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1500 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaab5e4b0a7c65d1b71b5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18517/7/9/2?documentUUID=972e3094-2302-4550-b25c-8b3cf0ded92a; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=P0: mortality|P0: body weight and weight gain|P0: urinalysis|P0: gross pathology|P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|gross pathology|mortality/survival|reproduction|urinalysis; STUDY_GROUP=ECHA IUCLID:15857648:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9951462fc4a592053696550e7a59b41c
openFDA substances 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier TDQ283MPCW UNII - - - chemical {"approval_status":null,"molecular_formula":"C20H6Br4O5.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"TDQ283MPCW"}
openFDA substances FDA UNII substance identifier 1678RKX8RT UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"1678RKX8RT"}
openFDA substances FDA UNII substance identifier TDQ283MPCW UNII - - - chemical {"approval_status":null,"molecular_formula":"C20H6Br4O5.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"TDQ283MPCW"}
openFDA substances FDA UNII substance identifier TDQ283MPCW UNII - - - chemical {"approval_status":null,"molecular_formula":"C20H6Br4O5.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"TDQ283MPCW"}
openFDA substances FDA UNII substance identifier 1678RKX8RT UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"1678RKX8RT"}
openFDA substances FDA UNII substance identifier 1678RKX8RT UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"1678RKX8RT"}
openFDA substances FDA UNII substance identifier TDQ283MPCW UNII - - - chemical {"approval_status":null,"molecular_formula":"C20H6Br4O5.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"TDQ283MPCW"}
openFDA substances FDA UNII substance identifier 1678RKX8RT UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"1678RKX8RT"}