Is Acid Red 87 safe in cosmetics?
Acid Red 87 has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted. 1 toxicological study endpoint(s) are available in our database.
Acid Red 87
Also known as: EINECS 241-409-6, Eosine Extra Yellowish, Fenazo Eoxine XG, Japan Red 103, Japan Red 230-1 (+14 more)
INCI: CI 45380
Acid Red 87 (CAS 17372-87-1) is a cosmetic cosmetic ingredient functioning as Colorant (halogenated xanthene dye; Eosin Y / Eosin Yellowish). Reported NOAEL =1500 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 17372-87-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Acid Red 87 is classified GHS CMR hazard (H319, H341) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Colorant (halogenated xanthene dye; Eosin Y / Eosin Yellowish)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
disodium;2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate
InChIKey
SEACYXSIPDVVMV-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
D&C Red No. 22 — permanently listed, batch certification required; drugs and cosmetics generally
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acid Red 87.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Acid Red 87. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1500 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| ASEAN | permitted_colorant | - | All products |
Additional Ingredient Properties
2 property records from structured ingredient metadata.
colorant
{"Common_Name": "D&C Orange No. 5", "Chemical_Name": "Dibromofluorescein", "CAS_Number": "596-03-2", "Colorant_Type": "Synthetic Dye", "Approved_Uses": "External use only", "Max_Concentration_%": "No limit", "EU_Status": "Not approved", "US_FDA_Status": "Approved 21 CFR 74.1255", "Notes": "Fluorescent orange, US only"}
colorant_formulator
{"ci_number": "45380", "ci_name": "Pigment Red 90", "color_category": "red", "color_hex_code": "#C71585", "natural_or_synthetic": "synthetic", "organic_or_inorganic": "organic", "lake_or_dye": "pigment", "fda_approved_use": "general", "eu_approved_cosmetic": "yes", "japan_approved": "yes", "china_approved": "yes", "coverage_opacity": "transparent", "tinting_strength": "high", "lightfastness_rating…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (1)
JECFA Evaluation
CI PIGMENT RED 90 | 1964 | NMRS 38/TRS 309-JECFA 8/22
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU Restricted for Children (Cosmetics)
Expert Verdict
Expert safety assessment and concern-level summary for Acid Red 87.
Regulatory Flags
potential-allergen
colorant
eu_children_restricted
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Acid Red 87 by CAS number or substance name.
Studies
1
Lowest NOAEL
1500 mg/kg bw/day
Highest NOAEL
1500 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
EINECS 241-409-6
Eosine Extra Yellowish
Fenazo Eoxine XG
Japan Red 103
Japan Red 230-1
Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-, 2Na
2,4,5,7-Tetrabromofluorescein
2',4',5',7'-Tetrabromofluorescein disodium salt
Cerven kysela 87
Eosin gelblich
UNII-TDQ283MPCW
2',4',5',7'-Tetrabromo-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9-'-(9H)xanthen)-3-one, disodium salt
C.I. 45380
CI 45380 (Na salt)
D and C Red No. 22
Eosin Y ws
water soluble eosin
water-soluble eosin
eosin YS dye
Chemical Function
Dye
Regulatory Lists
Arts and crafts/Office supplies - body paint - tattoo ink; Europe
Arts and crafts/Office supplies - body paint - tattoo ink; Europe
children; Europe; Personal care
children; Europe; Personal care - specialized bath products - bath salts
children; Europe; Personal care
children; Europe; Personal care
pharmaceutical
Personal care
Canada; pharmaceutical
inert_ingredient; non_food_use; Pesticides
Canada; consumer_product; Substances in Products - Canada (4/2014)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
EOSIN Y SODIUM
ChEMBL ID
CHEMBL411675
Frequently Asked Questions
Is Acid Red 87 allowed in the EU?
Acid Red 87 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acid Red 87 do in cosmetics?
Acid Red 87 functions as: Colorant (halogenated xanthene dye; Eosin Y / Eosin Yellowish). It is classified as a cosmetic ingredient in our database. CAS number: 17372-87-1.
What is the NOAEL for Acid Red 87?
The NOAEL (No Observed Adverse Effect Level) for Acid Red 87 is =1500 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Acid Red 87 used outside cosmetics?
Acid Red 87 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Acid Red 87 have different safety status in cosmetics vs industrial chemicals?
Acid Red 87 is classified GHS CMR hazard (H319, H341) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Acid Red 87 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Colorant (red/pink xanthene dye)
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