Is Acid Blue 3 safe in cosmetics?
Acid Blue 3 has a safety rating of "GOOD" in our database. EU status: permitted. US status: prohibited.
Good
Cosmetic Ingredient
Acid Blue 3
INCI: CI 42051
Acid Blue 3 (CAS 3536-49-0) is a cosmetic cosmetic ingredient functioning as Colorant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 3536-49-0 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
calcium bis(4-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]-6-hydroxybenzene-1,3-disulfonate)
InChIKey
RTMBGDBBDQKNNZ-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
prohibited
US Notes
Not FDA-approved as a color additive for cosmetics. Not listed in 21 CFR Parts 73, 74, or 82.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acid Blue 3.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1356
(EC) 2013/344
Annex IV — Permitted Colorants
Product type: Blue
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1356
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
India: Permitted Colorant
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| ASEAN | permitted_colorant | - | All products |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
colorant
{"Common_Name": "D&C Blue No. 9", "Chemical_Name": "Indigotine disulphonic acid", "CAS_Number": "2650-18-2", "Colorant_Type": "Synthetic Dye", "Approved_Uses": "External use only", "Max_Concentration_%": "No limit", "EU_Status": "Approved", "US_FDA_Status": "Approved 21 CFR 74.109", "Notes": "Not for mucous membranes"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Evaluation
CI FOOD BLUE 5 | 1982 | NO ADI ALLOCATED | TRS 683-JECFA 26/23 | FAS 6/NMRS 54A-JECFA 18/106 (1974)
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (3)
EU Banned in Cosmetics
EU Restricted for Children (Cosmetics)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Acid Blue 3.
Regulatory Flags
colorant
eu_banned_cosmetics
eu_children_restricted
eu_cosing_listed
jecfa_concern
Chemical Function
Dye
Regulatory Lists
children; Europe; Personal care
children; Europe; Personal care - hair styling and care - shampoo
children; Europe; Personal care
children; Europe; Personal care
Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe
Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe
Cleaning products and household care; Europe
banned; Europe; Personal care
Europe; Personal care - hair styling and care - shampoo-dandruff
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
1
Frequently Asked Questions
Is Acid Blue 3 allowed in the EU?
Acid Blue 3 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acid Blue 3 do in cosmetics?
Acid Blue 3 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 3536-49-0.
Is Acid Blue 3 used outside cosmetics?
Acid Blue 3 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Acid Blue 3 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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