What is the NOAEL for Acid Blue 3?
Acid Blue 3 has 9 NOAEL studies in the database. The lowest reported value is 5 mg/kg bw/day in Consumers. Source: EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Acid Blue 3
CAS 3536-49-0
Acid Blue 3 (CAS 3536-49-0) is a chemical substance. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for CI 42051 (Patent Blue V / Acid Blue 3) →
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
9
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
6 fields
Name
Acid Blue 3
CAS Number
3536-49-0
DTXSID
DTXSID00873918
Molecular Formula
2C27H32N2O7S2.Ca
InChI Key
RTMBGDBBDQKNNZ-UHFFFAOYSA-L
Monoisotopic Mass
1160.292778
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
25 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
9 records
| List | Keyword | Source |
|---|---|---|
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe | Danish EPA | Danish EPA |
| Cleaning products and household care; Europe | Danish EPA | Danish EPA |
| banned; Europe; Personal care | European Commission | CosIng |
| Europe; Personal care - hair styling and care - shampoo-dandruff | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =5 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =5 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| 8QE473DV1Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8QE473DV1Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8QE473DV1Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8QE473DV1Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =500 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_EFSA |
| =500 | mg/kg bw/day | NOAEL | - | Mouse | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =500 | mg/kg bw/day | NOAEL | - | Mouse | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Bis[hydrogen [4-[4-(diethylamino)-5'-hydroxy-2',4'-disulphonatobenzhydrylidene]cyclohexa-2,5-dien-1-ylidene]diethylammonium], calcium salt | 222-573-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
Permitted in non-hair-dye cosmetics under Annex IV (Entry IV/60); prohibited in hair dye formulations (Annex II Entry 1356). Applies to free acid, calcium salt, and insoluble lakes/pigments thereof.
Category
Colorants
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ChEMBL Phase
Not listed
Adverse Events
1
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Acid Blue 3?
Acid Blue 3 appears on 7 regulatory/inventory lists including children; Europe; Personal care, children; Europe; Personal care - hair styling and care - shampoo, Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe, and 4 more. Source: EPA CPDat.
Is Acid Blue 3 used in cosmetics?
Yes, Acid Blue 3 is also indexed as a cosmetic ingredient under the name CI 42051 (Patent Blue V / Acid Blue 3). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Acid Blue 3 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Acid Blue 3 used outside industrial chemicals?
Acid Blue 3 also appears in cosmetics, pharmaceutical, cannabis databases.