Is Acetyl Dipeptide-1 Cetyl Ester safe in cosmetics?
Acetyl Dipeptide-1 Cetyl Ester has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Acetyl Dipeptide-1 Cetyl Ester
Also known as: UNII-3M7W78X5IR, L-Arginine, N-acetyl-L-tyrosyl-, hexadecyl ester, N-Acetyl dipeptide-1 cetyl ester, Sensicalmine
INCI: ACETYL DIPEPTIDE-1 CETYL ESTER
Acetyl Dipeptide-1 Cetyl Ester (CAS 196604-48-5) is a cosmetic active ingredient functioning as Neurotransmitter inhibitor dipeptide that stimulates nerve cells to release. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 196604-48-5 →
Auto-generated CPSR Part A draft with source citations
Function
Neurotransmitter inhibitor dipeptide that stimulates nerve cells to release met-enkephalin, an endogenous opioid peptide. Results in muscle relaxation and reduced skin inflammation. Mechanism is distinct from SNARE complex inhibitors and postsynaptic receptor antagonists, enabling multi-pathway combination formulation strategies.
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
hexadecyl (2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoate
InChIKey
JFHZXDZUXGBFAQ-KYJUHHDHSA-N
SMILES
CCCCCCCCCCCCCCCCOC(=O)C(CCCN=C(N)N)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; no US concentration cap. Used in neurocosmetic formulations targeting reactive skin.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acetyl Dipeptide-1 Cetyl Ester.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
3 property records from structured ingredient metadata.
anti_pollution
{"cas_number": "196604-48-5", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibi…
peptide
{"cas_number": "196604-48-5", "trade_name": "Calmosensine", "peptide_sequence_amino_acids": "Ac-Arg-Ala-Cetyl", "peptide_length_residues": "2", "molecular_weight_daltons": "552.8", "peptide_class": "signal", "mechanism_of_action": "Neuropeptide, reduces neurogenic inflammation and sensitive skin reactivity", "target_protein_or_receptor": "Substance P inhibition", "collagen_boost_pct_in_vitro": "15…
synergy
{"inci_name_2": "Ceramide Complex", "synergy_type": "efficacy-boost", "synergy_description": "Anti-inflammatory peptide with barrier lipids for sensitive skin", "combined_benefit": "Reduced redness, enhanced barrier repair, improved tolerance", "efficacy_multiplier": "2x", "mechanism_of_action": "Peptide reduces inflammation; ceramides restore barrier structure", "optimal_ratio": "1:6 (1% peptide …
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Acetyl Dipeptide-1 Cetyl Ester.
Regulatory Flags
active
peptide
neurogenic-modulator
neuropeptide-signaling
neurocosmetic
sensitive-skin
reactive-skin
anti-itch
Known Synonyms
UNII-3M7W78X5IR
L-Arginine, N-acetyl-L-tyrosyl-, hexadecyl ester
N-Acetyl dipeptide-1 cetyl ester
Sensicalmine
Chemical Function
Softener and conditioner
Frequently Asked Questions
Is Acetyl Dipeptide-1 Cetyl Ester allowed in the EU?
Acetyl Dipeptide-1 Cetyl Ester EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetyl Dipeptide-1 Cetyl Ester do in cosmetics?
Acetyl Dipeptide-1 Cetyl Ester functions as: Neurotransmitter inhibitor dipeptide that stimulates nerve cells to release met-enkephalin, an endogenous opioid peptide. Results in muscle relaxation and reduced skin inflammation. Mechanism is distinct from SNARE complex inhibitors and postsynaptic receptor antagonists, enabling multi-pathway combination formulation strategies.. It is classified as a Active Ingredient in our database. CAS number: 196604-48-5.
Compliance Tools
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MoS Calculator
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