What is the NOAEL for Acetoin?
Acetoin has 27 NOAEL studies in the database. The lowest reported value is BG4D34CO2H UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Acetoin
Also known as: 2-01-00-00870, Acethoin, BRN 0385636, EINECS 208-174-1, FEMA No. 2008 (+13 more)
CAS 513-86-0
Acetoin (CAS 513-86-0) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Acetoin is classified GHS Danger (H226, H228, H315, H318, H319) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
27
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
24 fields
Name
Acetoin
CAS Number
513-86-0
DTXSID
DTXSID0024399
Molecular Formula
C4H8O2
InChI Key
ROWKJAVDOGWPAT-UHFFFAOYSA-N
Monoisotopic Mass
88.052429
Synonyms
2-01-00-00870AcethoinBRN 0385636EINECS 208-174-1FEMA No. 2008UNII-BG4D34CO2H(R)-2-acetoin(R)-3-hydroxy-2-butanone(R)-3-hydroxybutan-2-one(R)-acetoin(R)-dimethylketol(S)-2-Acetoin
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
57 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 27 of 27 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| BG4D34CO2H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BG4D34CO2H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BG4D34CO2H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 6750 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =90 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =90 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 1320 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =0.015 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v042je20 |
| =0.015 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v042je20 |
| =5 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v042je20 |
| =5 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v042je20 |
| =17 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v042je20 |
| =17 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v042je20 |
| =50 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v042je20 |
| =50 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v042je20 |
| =90 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v042je20 |
| =90 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v042je20 |
| =200 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v042je20 |
| =200 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v042je20 |
| =330 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v042je20 |
| =330 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v042je20 |
| =400 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v042je20 |
| =400 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v042je20 |
| =500 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v042je20 |
| =500 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v042je20 |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 27 of 27 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Acetoin | 208-174-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3561873
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Acetoin?
Acetoin appears on 5 regulatory/inventory lists including Canada; pharmaceutical, Europe, IFRA Transparency, and 2 more. Source: EPA CPDat.
Is Acetoin used in cosmetics?
Yes, Acetoin is also indexed as a cosmetic ingredient under the name Acetoin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Acetoin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Acetoin have different safety status in cosmetics vs industrial chemicals?
Acetoin is classified GHS Danger (H226, H228, H315, H318, H319) in the chemicals database but is allowed in EU cosmetics.
Is Acetoin used outside industrial chemicals?
Acetoin also appears in cosmetics, pharmaceutical, food safety, cannabis databases.