Moderate Cosmetic Ingredient NOAEL Data

3,5-Dimethyl-3-Cyclohexene-1-Carbaldehyde

Also known as: 3-Cyclohexene-1-carboxaldehyde, dimethyl-, Dimethyl-3-cyclohexene-1-carboxaldehyde, Dimethylcyclohex-3-ene-1-carbaldehyde, Dimethylcyclohex-3-en-1-carbaldehyd, dimetilciclohex-3-eno-1-carbaldehido (+6 more)

INCI: 3,5-DIMETHYL-3-CYCLOHEXENE-1-CARBALDEHYDE

3,5-Dimethyl-3-Cyclohexene-1-Carbaldehyde (CAS 27939-60-2) is a cosmetic cosmetic ingredient functioning as Fragrance (Perfuming). Reported NOAEL =150 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.

View industrial chemical safety profile for CAS 27939-60-2 →

Auto-generated CPSR Part A draft with source citations
Function
Fragrance (Perfuming)
Safety Rating
MODERATE

Chemistry & Identifiers

Formula
C9H14O
MW
138.21 g/mol
EC Number
248-742-6
PubChem CID
3034463
IUPAC Name
1,2-dimethylcyclohex-3-ene-1-carbaldehyde
InChIKey
CYGGTUUCLIFNIU-UHFFFAOYSA-N

Regulatory Status

EU EU Status permitted
US US Status permitted
US Notes Not specifically restricted by FDA

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for 3,5-Dimethyl-3-Cyclohexene-1-Carbaldehyde.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for 3,5-Dimethyl-3-Cyclohexene-1-Carbaldehyde. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL =150 mg/kg bw/day oral Rat reproduction developmental ToxValDB_ECHA_IUCLID
NOAEL =500 mg/kg bw/day oral Rat short-term ToxValDB_ECHA_IUCLID

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Regulatory (2)
JECFA Number
1900
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
(2,4)-, (3,5)- and (3,6)-DIMETHYL-3-CYCLOHEXENYLCARBALDEHYDE | 2010 | No safety concern at current levels of intake when used as a flavouring agent | TRS 960-JECFA 73 | FAS 64-JECFA 73
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Flavouring and nutrient Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List FDA Substances Added to Food (EAFUS)

Expert Verdict

Expert safety assessment and concern-level summary for 3,5-Dimethyl-3-Cyclohexene-1-Carbaldehyde.

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance fda_food_additive

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to 3,5-Dimethyl-3-Cyclohexene-1-Carbaldehyde by CAS number or substance name.

Studies
2
Lowest NOAEL
150 mg/kg bw/day
Highest NOAEL
500 mg/kg bw/day
ToxValDB_ECHA_IUCLID

Known Synonyms

3-Cyclohexene-1-carboxaldehyde, dimethyl- Dimethyl-3-cyclohexene-1-carboxaldehyde Dimethylcyclohex-3-ene-1-carbaldehyde Dimethylcyclohex-3-en-1-carbaldehyd dimetilciclohex-3-eno-1-carbaldehido CYCLOHEX-3-ENE-1-CARBOXALDEHYDE, DIMETHYL- 3-Cyclohexene-1-Carboxaldehyde,Dimethyl EINECS 248-742-6 UNII-A5944Q44A4 Dimethyltetrahydrobenzaldehyde CC1=CC(C)CC(C=O)C1

Chemical Function

Fragrance

Regulatory Lists

food_additive; Substances Added to Food (formerly EAFUS) (2/2019) IFRA Transparency

Australian Status

AICIS status: listed

Frequently Asked Questions

Is 3,5-Dimethyl-3-Cyclohexene-1-Carbaldehyde safe in cosmetics?

3,5-Dimethyl-3-Cyclohexene-1-Carbaldehyde has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.

Is 3,5-Dimethyl-3-Cyclohexene-1-Carbaldehyde allowed in the EU?

3,5-Dimethyl-3-Cyclohexene-1-Carbaldehyde EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 3,5-Dimethyl-3-Cyclohexene-1-Carbaldehyde do in cosmetics?

3,5-Dimethyl-3-Cyclohexene-1-Carbaldehyde functions as: Fragrance (Perfuming). It is classified as a cosmetic ingredient in our database. CAS number: 27939-60-2.

What is the NOAEL for 3,5-Dimethyl-3-Cyclohexene-1-Carbaldehyde?

The NOAEL (No Observed Adverse Effect Level) for 3,5-Dimethyl-3-Cyclohexene-1-Carbaldehyde is =150 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.

Is 3,5-Dimethyl-3-Cyclohexene-1-Carbaldehyde used outside cosmetics?

3,5-Dimethyl-3-Cyclohexene-1-Carbaldehyde also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Is 3,5-Dimethyl-3-Cyclohexene-1-Carbaldehyde in Your Products?

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