Is 3,4-Methylenedioxyphenol safe in cosmetics?
3,4-Methylenedioxyphenol has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
3,4-Methylenedioxyphenol
Also known as: 5-19-02-00532, BRN 0127405, EINECS 208-561-5, Methylene ether of oxyhydroquinone, UNII-94IEA0NV89
INCI: 3,4-METHYLENEDIOXYPHENOL
3,4-Methylenedioxyphenol (CAS 533-31-3) is a cosmetic cosmetic ingredient functioning as Hair dye precursor, Antioxidant. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 533-31-3 →
Auto-generated CPSR Part A draft with source citations
Function
Hair dye precursor, Antioxidant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1,3-benzodioxol-5-ol
InChIKey
LUSZGTFNYDARNI-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Not on FDA's prohibited list for general cosmetic use; however, limited cosmetic application
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 3,4-Methylenedioxyphenol.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1247
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1247
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Flavouring and nutrient
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 3,4-Methylenedioxyphenol.
Regulatory Flags
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
5-19-02-00532
BRN 0127405
EINECS 208-561-5
Methylene ether of oxyhydroquinone
UNII-94IEA0NV89
Chemical Function
Dye
Flavouring and nutrient
Regulatory Lists
banned; Europe; Personal care
Europe
pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1517998
Frequently Asked Questions
Is 3,4-Methylenedioxyphenol allowed in the EU?
3,4-Methylenedioxyphenol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does 3,4-Methylenedioxyphenol do in cosmetics?
3,4-Methylenedioxyphenol functions as: Hair dye precursor, Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 533-31-3.
Is 3,4-Methylenedioxyphenol used outside cosmetics?
3,4-Methylenedioxyphenol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 3,4-Methylenedioxyphenol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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