Is 3-Phenylbutyraldehyde safe in cosmetics?
3-Phenylbutyraldehyde has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
3-Phenylbutyraldehyde
Also known as: 3-Phenylbutanal, Benzenepropanal, beta-methyl-, Benzenepropanal, .beta.-methyl-, EINECS 240-362-9, 3-Methyl-3-phenylpropanal
INCI: 3-PHENYLBUTYRALDEHYDE
3-Phenylbutyraldehyde (CAS 16251-77-7) is a cosmetic cosmetic ingredient functioning as Fragrance with green, herbal, hyacinth odor profile. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 16251-77-7 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance with green, herbal, hyacinth odor profile
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3-phenylbutanal
InChIKey
MYHGOWDLVRDUFA-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted with no specific FDA restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 3-Phenylbutyraldehyde.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 102 | 0 | 5905 | 5905 | non-sensitizer |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for 3-Phenylbutyraldehyde.
Regulatory Flags
fragrance-component
ifra_fragrance
Known Synonyms
3-Phenylbutanal
Benzenepropanal, beta-methyl-
Benzenepropanal, .beta.-methyl-
EINECS 240-362-9
3-Methyl-3-phenylpropanal
Chemical Function
Fragrance
Regulatory Lists
IFRA Transparency
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3187537
Frequently Asked Questions
Is 3-Phenylbutyraldehyde allowed in the EU?
3-Phenylbutyraldehyde EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 3-Phenylbutyraldehyde do in cosmetics?
3-Phenylbutyraldehyde functions as: Fragrance with green, herbal, hyacinth odor profile. It is classified as a cosmetic ingredient in our database. CAS number: 16251-77-7.
Is 3-Phenylbutyraldehyde used outside cosmetics?
3-Phenylbutyraldehyde also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 3-Phenylbutyraldehyde compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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