Is 3-Octanol safe in cosmetics?
3-Octanol has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
3-Octanol
Also known as: (+/-)-3-Octanol, 1-Ethylhexanol, Amylethylcarbinol, Ethyl amyl carbinol, DL-3-Octanol (+2 more)
INCI: 3-OCTANOL
3-Octanol (CAS 589-98-0) is a cosmetic cosmetic ingredient functioning as Fragrance. NOAEL 25 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 589-98-0 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
octan-3-ol
InChIKey
NMRPBPVERJPACX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS status; no FDA-specific cosmetic restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 3-Octanol.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 3-Octanol across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 8100 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
291
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3-OCTANOL | 1998 | No safety concern at current levels of intake when used as a flavouring agent | TRS 891-JECFA 51/59 | FAS 42-JECFA 51/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for 3-Octanol.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
(+/-)-3-Octanol
1-Ethylhexanol
Amylethylcarbinol
Ethyl amyl carbinol
DL-3-Octanol
Ethylamylcarbinol
n-Octan-3-ol
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
3-OCTANOL
ChEMBL ID
CHEMBL487998
Frequently Asked Questions
Is 3-Octanol allowed in the EU?
3-Octanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 3-Octanol do in cosmetics?
3-Octanol functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 589-98-0.
Is 3-Octanol used outside cosmetics?
3-Octanol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 3-Octanol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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