Is 2-Isopropyl-5-Methylanisole safe in cosmetics?
2-Isopropyl-5-Methylanisole has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
2-Isopropyl-5-Methylanisole
Also known as: methyl 5-methyl-2-(propan-2-yl)phenyl ether, 1-Isopropyl-2-methoxy-4-methylbenzene, 2-Methoxy-4-methyl-1-(propan-2-yl)benzene, Benzene, 2-methoxy-4-methyl-1-(1-methylethyl)-, 4-06-00-03335 (+15 more)
2-Isopropyl-5-Methylanisole (CAS 1076-56-8) is a cosmetic cosmetic ingredient functioning as Flavouring and nutrient; Fragrance. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 1076-56-8 →
Auto-generated CPSR Part A draft with source citations
Function
Flavouring and nutrient; Fragrance
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-methoxy-4-methyl-1-propan-2-ylbenzene
InChIKey
LSQXNMXDFRRDSJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS 3436 for flavor use; no FDA cosmetic prohibition
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Isopropyl-5-Methylanisole.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (6)
JECFA Number
1246
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
1-ISOPROPYL-2-METHOXY-4-METHYLBENZENE | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/86 | FAS 52-JECFA 61/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
1-METHYL-3-METHOXY-4-ISOPROPYLBENZENE | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/86 | FAS 52-JECFA 61/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-ISOPROPYL-5-METHYLANISOLE | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/86 | FAS 52-JECFA 61/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3-METHOXY-p-CYMENE | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/86 | FAS 52-JECFA 61/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for 2-Isopropyl-5-Methylanisole.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
methyl 5-methyl-2-(propan-2-yl)phenyl ether
1-Isopropyl-2-methoxy-4-methylbenzene
2-Methoxy-4-methyl-1-(propan-2-yl)benzene
Benzene, 2-methoxy-4-methyl-1-(1-methylethyl)-
4-06-00-03335
BRN 2042889
EINECS 214-063-9
FEMA No. 3436
4-Isopropyl-3-methoxytoluene
3-Methoxy-p-cymene
2-Methoxy-4-methyl-1-(1-methylethyl)benzene
Methyl thymol ether
Methyl thymyl ether
1-Methyl-3-methoxy-4-isopropylbenzene
Methylthymol, o-
O-Methylthymol
NSC 404221
Thymol methyl ether
Thymyl methyl ether
UNII-VTE0C4390U
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL2424841
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
1-METHYL-3-METHOXY-4-ISOPROPYLBENZENE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is 2-Isopropyl-5-Methylanisole allowed in the EU?
2-Isopropyl-5-Methylanisole EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Isopropyl-5-Methylanisole do in cosmetics?
2-Isopropyl-5-Methylanisole functions as: Flavouring and nutrient; Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 1076-56-8.
Is 2-Isopropyl-5-Methylanisole used outside cosmetics?
2-Isopropyl-5-Methylanisole also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 2-Isopropyl-5-Methylanisole compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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