Is 2-Hydroxyethylamino-5-Nitroanisole safe in cosmetics?
2-Hydroxyethylamino-5-Nitroanisole has a safety rating of "GOOD" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
2-Hydroxyethylamino-5-Nitroanisole
INCI: 2-HYDROXYETHYLAMINO-5-NITROANISOLE
2-Hydroxyethylamino-5-Nitroanisole (CAS 66095-81-6) is a cosmetic cosmetic ingredient functioning as Hair dyeing — semi-permanent (non-oxidative) direct dye. Reported NOAEL =100 mg/kg/day in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: prohibited, max 0.2%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 66095-81-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2-Hydroxyethylamino-5-Nitroanisole is prohibited in EU cosmetics at max 0.2% but has active industrial GHS classifications (H302, H315, H319, H335).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dyeing — semi-permanent (non-oxidative) direct dye
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-(2-methoxy-4-nitroanilino)ethanol
InChIKey
DZFVBIGUJAYIFJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
EU Max Conc.
0.2%
US US Status
permitted
US Notes
Permitted in hair dye products; no specific FDA restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Hydroxyethylamino-5-Nitroanisole.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for 2-Hydroxyethylamino-5-Nitroanisole. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =100 mg/kg/day | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =100 mg/kg bw/day | oral | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =100 mg/kg/day | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =100 mg/kg bw/day | oral | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =100 mg/kg/day | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =100 mg/kg bw/day | oral | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =100 mg/kg/day | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =100 mg/kg bw/day | oral | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =250 mg/kg bw/day | oral | human | NOAEL study | SCCS_vision_codex |
| NOAEL | =250 mg/kg bw/day | oral | human | NOAEL study | SCCS_vision_codex |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in non-oxidative hair dye products. Max: 0.2%%.
BRIN Brazil/India Cosmetics
India: Restricted · max 0.2%%
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (3 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.64% | - | - | SCCP/0109 |
| measured | 0.21% | - | - | SCCP/0109 |
| measured | 2.5% | - | - | SCCP/0109 |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "66095-81-6", "ingredient_class": "direct_dye", "chemical_class": "nitro", "color_result_on_hair": "Yellow-brown", "shade_range": "brown", "primary_function": "direct_deposit", "requires_developer": "no", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "6-10", "light_fastness": "moderate", "oxidation_mechanism": "direct_absorption", "hair_penetration…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 2-Hydroxyethylamino-5-Nitroanisole.
Regulatory Flags
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 2-Hydroxyethylamino-5-Nitroanisole by CAS number or substance name.
Studies
12
Lowest NOAEL
100
Highest NOAEL
250
Units vary across source rows: mg/kg/day, mg/kg bw/day
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.64% | - | - |
| 0.21% | - | - |
| 2.5% | - | - |
Chemical Function
Dye
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Frequently Asked Questions
Is 2-Hydroxyethylamino-5-Nitroanisole allowed in the EU?
2-Hydroxyethylamino-5-Nitroanisole EU regulatory status: prohibited. Maximum allowed concentration: 0.2%. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Hydroxyethylamino-5-Nitroanisole do in cosmetics?
2-Hydroxyethylamino-5-Nitroanisole functions as: Hair dyeing — semi-permanent (non-oxidative) direct dye. It is classified as a cosmetic ingredient in our database. CAS number: 66095-81-6.
What is the NOAEL for 2-Hydroxyethylamino-5-Nitroanisole?
The NOAEL (No Observed Adverse Effect Level) for 2-Hydroxyethylamino-5-Nitroanisole is =100 mg/kg/day based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is 2-Hydroxyethylamino-5-Nitroanisole used outside cosmetics?
2-Hydroxyethylamino-5-Nitroanisole also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2-Hydroxyethylamino-5-Nitroanisole have different safety status in cosmetics vs industrial chemicals?
2-Hydroxyethylamino-5-Nitroanisole is prohibited in EU cosmetics at max 0.2% but has active industrial GHS classifications (H302, H315, H319, H335).
Compliance Tools
Check 2-Hydroxyethylamino-5-Nitroanisole compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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