What is the NOAEL for 2-Hydroxyethylamino-5-nitroanisole?
2-Hydroxyethylamino-5-nitroanisole has 23 NOAEL studies in the database. The lowest reported value is 100 mg/kg bw/day via oral. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.
NOAEL Data
Cosmetic Ingredient
2-Hydroxyethylamino-5-nitroanisole
CAS 66095-81-6
2-Hydroxyethylamino-5-nitroanisole (CAS 66095-81-6) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
View cosmetic safety profile for 2-Hydroxyethylamino-5-Nitroanisole →
Cross-Vertical Regulatory Divergence
2-Hydroxyethylamino-5-nitroanisole is prohibited in EU cosmetics at max 0.2% but has active industrial GHS classifications (H302, H315, H319, H335).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
23
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
6 fields
Name
2-Hydroxyethylamino-5-nitroanisole
CAS Number
66095-81-6
DTXSID
DTXSID50867206
Molecular Formula
C9H12N2O4
InChI Key
DZFVBIGUJAYIFJ-UHFFFAOYSA-N
Monoisotopic Mass
212.079707
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 23 of 23 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 100 | mg/kg bw/day | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 250 | mg/kg bw/day | - | oral | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 249S4E2270 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 249S4E2270 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 249S4E2270 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 249S4E2270 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 25 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| =100 | mg/kg/day | NOAEL | oral | rat | SCCS_vision_codex |
| =100 | mg/kg bw/day | NOAEL | oral | - | SCCS_vision_codex |
| =100 | mg/kg/day | NOAEL | oral | rat | SCCS_vision_codex |
| =100 | mg/kg bw/day | NOAEL | oral | - | SCCS_vision_codex |
| =100 | mg/kg/day | NOAEL | oral | rat | SCCS_vision_codex |
| =100 | mg/kg bw/day | NOAEL | oral | - | SCCS_vision_codex |
| =100 | mg/kg/day | NOAEL | oral | rat | SCCS_vision_codex |
| =100 | mg/kg bw/day | NOAEL | oral | - | SCCS_vision_codex |
| =250 | mg/kg bw/day | NOAEL | oral | human | SCCS_vision_codex |
| =250 | mg/kg bw/day | NOAEL | oral | human | SCCS_vision_codex |
| =250 | mg/kg bw/day | NOAEL | oral | human | SCCS_vision_codex |
| =250 | mg/kg bw/day | NOAEL | oral | human | SCCS_vision_codex |
| 100 | mg/kg/day | dermal absorption | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 100 | mg/kg bw/day | dermal absorption | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 100 | mg/kg bw/day | irritation | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 100 | mg/kg bw/day | repeated dose toxicity | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
Showing 23 of 23 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
0.2%
Category
Colorant
Frequently Asked Questions
What regulatory lists include 2-Hydroxyethylamino-5-nitroanisole?
2-Hydroxyethylamino-5-nitroanisole appears on 2 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), Europe; Personal care; restricted. Source: EPA CPDat.
Is 2-Hydroxyethylamino-5-nitroanisole used in cosmetics?
Yes, 2-Hydroxyethylamino-5-nitroanisole is also indexed as a cosmetic ingredient under the name 2-Hydroxyethylamino-5-Nitroanisole. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Hydroxyethylamino-5-nitroanisole come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Hydroxyethylamino-5-nitroanisole have different safety status in cosmetics vs industrial chemicals?
2-Hydroxyethylamino-5-nitroanisole is prohibited in EU cosmetics at max 0.2% but has active industrial GHS classifications (H302, H315, H319, H335).
Is 2-Hydroxyethylamino-5-nitroanisole used outside industrial chemicals?
2-Hydroxyethylamino-5-nitroanisole also appears in cosmetics databases.