Is 2-Amino-5-Nitrophenol safe in cosmetics?
2-Amino-5-Nitrophenol has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
2-Amino-5-Nitrophenol
Also known as: 3-Hydroxy-4-aminonitrobenzene, 2-Hydroxy-4-nitroaniline, 3-Nitro-6-aminophenol, Phenol, 2-amino-5-nitro-, BRN 0972974 (+6 more)
INCI: 2-AMINO-5-NITROPHENOL
2-Amino-5-Nitrophenol (CAS 121-88-0) is a cosmetic cosmetic ingredient functioning as Hair dyeing. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 121-88-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2-Amino-5-Nitrophenol is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335, H351, H411, H317).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dyeing
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-amino-5-nitrophenol
InChIKey
DOPJTDJKZNWLRB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
CIR concluded safe as a hair dye ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Amino-5-Nitrophenol.
Calculate MoS for your specific formulation with the MoS Calculator.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
57
Evaluation Year
1992
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 384
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 384
JPKR Japan/Korea Cosmetics
Korea (Prohibited): Reclassified prohibited for hair dyes (2024)
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (4)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | banned | - | all cosmetics |
| CA | banned | - | - |
| ASEAN | banned | - | All cosmetic products prohibited |
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Carcinogen Classification
2-Amino-5-nitrophenol | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 57: (1993) Occupational Exposures of Hairdressers and Barbers and Personal Use of Hair Colourants; Some Hair Dyes, Cosmetic Colourants, Industrial Dyestuffs and Aromatic Amines
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
2-Amino-5-Nitrophenol | TR-334: Toxicology and Carcinogenesis Studies of 2-Amino-5-Nitrophenol (CASRN 121-88-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (1988 ) | 03/04/87 | Some Evidence | No Evidence | No Evidence | No Evidence | Under the conditions of these 2-year gavage studies, there was some evidence of carcinogenic activity for male F344/N rats that received 100 mg/kg 2-ami
Source: NTP Technical Reports
Evidence for Carcinogenicity
Evaluation: There is inadequate evidence in humans for the carcinogenicity of 2-amino-5-nitrophenol. There is limited evidence in experimental animals for the carcinogenicity of 2-amino-5-nitrophenol. Overall evaluation: 2-Amino-5-nitrophenol is not classifiable as to its carcinogenicity to humans (Group 3).
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 2-Amino-5-Nitrophenol.
Regulatory Flags
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
3-Hydroxy-4-aminonitrobenzene
2-Hydroxy-4-nitroaniline
3-Nitro-6-aminophenol
Phenol, 2-amino-5-nitro-
BRN 0972974
EINECS 204-503-8
NCI C55970
NSC 7087
Rodol YBA
Ursol Yellow Brown A
UNII-0149H05U82
Chemical Function
Dye
Regulatory Lists
banned; Europe; Personal care
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL164989
Frequently Asked Questions
Is 2-Amino-5-Nitrophenol allowed in the EU?
2-Amino-5-Nitrophenol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Amino-5-Nitrophenol do in cosmetics?
2-Amino-5-Nitrophenol functions as: Hair dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 121-88-0.
Is 2-Amino-5-Nitrophenol used outside cosmetics?
2-Amino-5-Nitrophenol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2-Amino-5-Nitrophenol have different safety status in cosmetics vs industrial chemicals?
2-Amino-5-Nitrophenol is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335, H351, H411, H317).
Compliance Tools
Check 2-Amino-5-Nitrophenol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acid Blue 9
Excellent
Same category
Colorant, Hair Dyeing
Acid Blue 9 Aluminum Lake
Excellent
Same category
Colorant
Anthocyanins
Excellent
Same category
Colorant
Beta Vulgaris Extract
Excellent
Same category
Skin Conditioning, Colorant (betalain...
Beta Vulgaris Root Extract
Excellent
Same category
Skin Conditioning, Colorant (betanin/...
Beta Vulgaris Root Powder
Excellent
Same category
Skin conditioning, natural colorant, ...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
2-Tert-Butylhydroquinone Methyl Ether
Moderate
Chemical family
Fragrance; Fragrance Functional (exci...
Benzethonium Chloride
Moderate
Chemical family
Antimicrobial Preservative, Cosmetic ...
Ethyl 3-Phenylglycidate
Good
Chemical family
Fragrance (perfuming agent), known as...
Is 2-Amino-5-Nitrophenol in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 2-Amino-5-Nitrophenol in your formulation.