What is the NOAEL for 2-Amino-5-nitrophenol?
2-Amino-5-nitrophenol has 13 NOAEL studies in the database. The lowest reported value is 0149H05U82 UNII. Source: openFDA substances.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
2-Amino-5-nitrophenol
Also known as: 3-Hydroxy-4-aminonitrobenzene, 2-Hydroxy-4-nitroaniline, 3-Nitro-6-aminophenol, Phenol, 2-amino-5-nitro-, BRN 0972974 (+6 more)
CAS 121-88-0
2-Amino-5-nitrophenol (CAS 121-88-0) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH.
Cross-Vertical Regulatory Divergence
2-Amino-5-nitrophenol is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335, H351, H411, H317).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
2-Amino-5-nitrophenol
CAS Number
121-88-0
DTXSID
DTXSID1020063
Molecular Formula
C6H6N2O3
InChI Key
DOPJTDJKZNWLRB-UHFFFAOYSA-N
Monoisotopic Mass
154.037842
Synonyms
3-Hydroxy-4-aminonitrobenzene2-Hydroxy-4-nitroaniline3-Nitro-6-aminophenolPhenol, 2-amino-5-nitro-BRN 0972974EINECS 204-503-8NCI C55970NSC 7087Rodol YBAUrsol Yellow Brown AUNII-0149H05U82
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1992 | 57 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0149H05U82 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0149H05U82 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0149H05U82 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0149H05U82 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| >2500 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >4000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| <100 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
| 200 | mg/kg bw/day | Top dose | Gavage | Rat | NTP_ICE_cancer |
| 800 | mg/kg bw/day | Top dose | Gavage | Mouse | NTP_ICE_cancer |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-amino-5-nitrophenol | 204-503-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL164989
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What regulatory lists include 2-Amino-5-nitrophenol?
2-Amino-5-nitrophenol appears on 1 regulatory/inventory list including banned; Europe; Personal care. Source: EPA CPDat.
Is 2-Amino-5-nitrophenol a carcinogen according to IARC?
2-Amino-5-nitrophenol is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1992). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is 2-Amino-5-nitrophenol used in cosmetics?
Yes, 2-Amino-5-nitrophenol is also indexed as a cosmetic ingredient under the name 2-Amino-5-Nitrophenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Amino-5-nitrophenol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Amino-5-nitrophenol have different safety status in cosmetics vs industrial chemicals?
2-Amino-5-nitrophenol is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335, H351, H411, H317).
Is 2-Amino-5-nitrophenol used outside industrial chemicals?
2-Amino-5-nitrophenol also appears in cosmetics, pharmaceutical databases.