Is 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE safe in cosmetics?
2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE has a safety rating of "MODERATE" in our database. EU status: restricted. 10 toxicological study endpoint(s) are available in our database.
2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE
2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE (CAS 1603-02-7) is a cosmetic cosmetic ingredient functioning as Hair Dyeing. Reported NOAEL =200 mg/kg bw in rat (SCCNFP_vision_codex); EU Regulation 1223/2009 status: restricted, max III/301. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 1603-02-7 →
Auto-generated CPSR Part A draft with source citations
Function
Hair Dyeing
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(2,5,6-triaminopyrimidin-4-yl) hydrogen sulfate
InChIKey
DJUGBKWOBAOTFA-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
III/301
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
10 study endpoints found for 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =200 mg/kg bw | oral | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =200 mg/kg bw | oral | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =200 mg/kg bw | oral | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =200 mg/kg bw | oral | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =1000 mg/kg bw | - | rat | dermal absorption | SCCNFP_vision_codex |
| NOAEL | =1000 mg/kg bw | - | rat | dermal absorption | SCCNFP_vision_codex |
| NOAEL | =1000 mg/kg bw | - | rat | dermal absorption | SCCNFP_vision_codex |
| NOAEL | =1000 mg/kg bw | - | rat | dermal absorption | SCCNFP_vision_codex |
| NOAEL | =0.83 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.83 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in oxidative hair dye products.
BRIN Brazil/India Cosmetics
India: Restricted
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (5 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 100.0% | - | - | SCCP/0144 |
| measured | 3.16% | - | - | SCCP/0144 |
| measured | 1.57% | - | - | SCCP/0144 |
| measured | 2.25% | - | - | SCCP/0144 |
| measured | 2.98% | - | - | SCCP/0144 |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "1603-02-7", "ingredient_class": "oxidative_dye_precursor", "chemical_class": "other", "molecular_weight_Da": "238.22", "color_result_on_hair": "Violet-ash", "shade_range": "brown", "primary_function": "precursor", "oxidative_dye_type": "primary_intermediate", "requires_developer": "yes", "permanence": "permanent", "oxidation_mechanism": "coupling", "hair_penetration_depth": "cortex…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE.
Regulatory Flags
cosing-sourced
eu-restricted
needs-enrichment
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE by CAS number or substance name.
Studies
28
Lowest NOAEL
0.83
Highest NOAEL
1000
Units vary across source rows: mg/kg bw/day, mg/kg bw/d, mg/kg bw
SCCS_vision_codex
SCCNFP_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 100.0% | - | - |
| 3.16% | - | - |
| 1.57% | - | - |
| 2.25% | - | - |
| 2.98% | - | - |
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Frequently Asked Questions
Is 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE allowed in the EU?
2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE EU regulatory status: restricted. Maximum allowed concentration: III/301. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE do in cosmetics?
2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE functions as: Hair Dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 1603-02-7.
What is the NOAEL for 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE?
The NOAEL (No Observed Adverse Effect Level) for 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE is =200 mg/kg bw based on a repeated dose toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCNFP_vision_codex.
Is 2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE used outside cosmetics?
2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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