What is the GHS hazard classification for Acetophenone?
Acetophenone (CAS 98-86-2) is classified under EU CLP Annex VI as Acute Tox. 4 *; Eye Irrit. 2 with signal word Warning. Hazard statements: H302; H319. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Acetophenone
Also known as: ethanone, 1-phenyl-, Benzene, acetyl-, EINECS 202-708-7, FEMA No. 2009, FEMA Number 2009 (+15 more)
CAS 98-86-2
Acetophenone (CAS 98-86-2) is a chemical substance with GHS signal word Warning; key hazard signal: H302; H319. Key regulatory status: REACH registered, 32 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA, EPA TRI.
SOURCE
noael studies public
NOAEL studies
36
SOURCE
chemical inventory jurisdictions
Regulatory lists
32
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Acetophenone
CAS Number
98-86-2
DTXSID
DTXSID6021828
Molecular Formula
C8H8O
InChI Key
KWOLFJPFCHCOCG-UHFFFAOYSA-N
Monoisotopic Mass
120.057515
Synonyms
ethanone, 1-phenyl-Benzene, acetyl-EINECS 202-708-7FEMA No. 2009FEMA Number 2009RCRA waste number U004USAF EK-496UNII-RK493WHV101-Phenyl-Ethanone1-Phenylethan-1-one1-Phenylethanone (acetophenone)1-Phenylethanone, 9CI
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Eye Irrit. 2 | H302; H319 | GHS07 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Harmful if swallowed May be harmful in contact with skin Causes eye irritation |
| Short-term Effects | The substance is irritating to the eyes. The substance may cause effects on the central nervous system. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
1 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| CAL/OSHA | TWA | 10 ppm (49 mg/m³) | 10 | 49 | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceDeodorizerNo specific technical functionFlavouring and nutrientSolvent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
32 records
| List | Keyword | Source |
|---|---|---|
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; Batteries; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; emissions; Europe; Other indirect contact consumer goods; water | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| artificial_saliva; artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
| detected; Toys and children's products | Springer | Published Articles |
| detected; Toys and children's products | Scientific Reports | Published Articles |
| detected; MN Chemical Screening; surface_water | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| IFRA Transparency | IFRA | IFRA |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 36 of 36 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| - | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =1.23 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| RK493WHV10 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RK493WHV10 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RK493WHV10 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RK493WHV10 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.326 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| >810 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =815 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| =900 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| <1000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1139 | mg/kg bw | LD50 | oral | Rat (Female) | NTP_ICE_acute_oral |
| =2081 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2200 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2650 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3000 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| =54055.9 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =750 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =50 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| <75 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 102 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =125 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =170 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =225 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =250 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 300 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =423 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_IRIS |
| =423 | mg/kg/day | NOAEL | oral | - | EPA_IRIS_iris_rfd_systems.csv |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| >=500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =780 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =0.1 | mg/kg bw/day | RfD | oral | Human | ToxValDB_IRIS |
| =0.1 | mg/kg/day | RfD | oral | - | EPA_IRIS_iris_rfd_systems.csv |
| =0.8 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 36 of 36 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Acetophenone | 202-708-7 | ECHA overview → |
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
SOURCE
EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| Acetophenone | - | - |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ACETOPHENONE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Acetophenone?
Acetophenone has 36 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
What regulatory lists include Acetophenone?
Acetophenone appears on 24 regulatory/inventory lists including air; Cons electronics mech appliances and machinery; detected; emissions; Europe, Cons electronics mech appliances and machinery; detected; emissions; Europe, detected; Europe; Other direct contact consumer goods, and 21 more. Source: EPA CPDat.
What are the occupational exposure limits for Acetophenone?
Occupational exposure limits for Acetophenone are set by CAL/OSHA. 1 limit value from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Acetophenone used in cosmetics?
Yes, Acetophenone is also indexed as a cosmetic ingredient under the name Acetophenone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Acetophenone come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Acetophenone used outside industrial chemicals?
Acetophenone also appears in cosmetics, pharmaceutical, cannabis databases.