What is the NOAEL for Coumarin?
Coumarin has 84 NOAEL studies in the database. The lowest reported value is -14.9 % via Dermal. Source: NTP ICE skin sensitization.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
Coumarin
Also known as: 2H-1-Benzopyran-2-one, Chromen-2-one, 5-17-10-00143, 2H-1-Benzopyran, 2-oxo-, 2H-Benzo(b)pyran-2-one (+15 more)
CAS 91-64-5
Coumarin (CAS 91-64-5) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 38 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, IARC, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
Coumarin is classified GHS Danger (H301, H302, H317) in the chemicals database but is restricted in EU cosmetics at max 10 ppm in leave-on products, 100 ppm in rinse-off products.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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NOAEL studies
NOAEL studies
84
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Chemical inventory jurisdictions
Regulatory lists
38
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EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
26 fields
Name
Coumarin
CAS Number
91-64-5
DTXSID
DTXSID7020348
Molecular Formula
C9H6O2
InChI Key
ZYGHJZDHTFUPRJ-UHFFFAOYSA-N
Monoisotopic Mass
146.036779
Synonyms
2H-1-Benzopyran-2-oneChromen-2-one5-17-10-001432H-1-Benzopyran, 2-oxo-2H-Benzo(b)pyran-2-oneBenzo-alpha-pyrone5,6-Benzo-alpha-pyroneBRN 0383644Caswell No. 259CCinnamic acid, o-hydroxy-, delta-lactonecis-o-Coumaric acid anhydrideo-Coumaric acid lactone
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 2000 | Sup 7, 77 |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
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WHO/JECFA
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the skin. |
| Long-term Effects | This substance is possibly carcinogenic to humans. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Fragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
38 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
| Europe | Danish Environmental Protection Agency | Danish EPA |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - body hygiene - hand soap | Danish Environmental Protection Agency | Danish EPA |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; detected; Europe; Personal care - body hygiene - hand soap | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - make-up and related | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - make-up and related | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - general household cleaning; Cleaning products and household care - laundry and fabric treatment; detected; Europe; Other direct contact consumer goods; Vehicle - car surface treatment - body cleaner | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| detected; Toys and children's products | Springer | Published Articles |
| IFRA Transparency | IFRA | IFRA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe | Danish EPA | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| artificial_sweat; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 84 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 151.78 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| >1023.015 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| >200 | ug/mL | CV70 | Dermal | - | NTP ICE skin sensitization |
| 537 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 537.4 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| - | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 20.8 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 29.2 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 4 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| 8 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| =6.78 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 1 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| -14.9 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 0.5 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 60.03 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 19.2 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 19.2 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 19.2 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 19.2 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 45.7 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 45.7 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 45.7 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 45.7 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 480 | uM | EC3 | Dermal | - | NTP ICE skin sensitization |
| A4VZ22K1WT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A4VZ22K1WT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A4VZ22K1WT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A4VZ22K1WT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.1922 | fraction | Fu | - | Human | NTP ICE adme parameters |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP ICE cancer |
| 1844.22 | uM | IC50 | Dermal | - | NTP ICE skin sensitization |
| 35.22 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 1.37 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 1.923 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 4966 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 5039 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 5669 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 14740 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 18390 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 2835 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP ICE skin sensitization |
| =25 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =25 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =50 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
| =50 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =75 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =75 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =300 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
| =300 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
Showing 50 of 84 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Coumarin | 202-086-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
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SCCS Opinion
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/0935/05 | 20 June 2006 | Contact allergen confirmed even at 99.9% purity; remains on mandatory labelling list; not recommended for de-listing. No new maximum concentration limit set. | No upper concentration limit set; mandatory labelling required when present above 10 ppm (0.001%) in leave-on and 100 ppm (0.01%) in rinse-off | Contact sensitisation confirmed even at 99.9% purity; impurities (3,4-dihydrocoumarin; 6-chlorocoumarin) are stronger sensitisers; hepatotoxicity concern |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
10 ppm in leave-on products, 100 ppm in rinse-off products
Category
fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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ChEMBL / DailyMed
COUMARIN
ChEMBL Phase
4
Adverse Events
6
Bioactivity
24
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Coumarin?
Coumarin appears on 28 regulatory/inventory lists including Europe; Personal care; restricted, Europe, Canada; consumer_product; Substances in Products - Canada (4/2014), and 25 more. Source: EPA CPDat.
Is Coumarin a carcinogen according to IARC?
Coumarin is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 2000). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Coumarin used in cosmetics?
Yes, Coumarin is also indexed as a cosmetic ingredient under the name Coumarin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Coumarin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Coumarin have different safety status in cosmetics vs industrial chemicals?
Coumarin is classified GHS Danger (H301, H302, H317) in the chemicals database but is restricted in EU cosmetics at max 10 ppm in leave-on products, 100 ppm in rinse-off products.
Is Coumarin used outside industrial chemicals?
Coumarin also appears in cosmetics, pharmaceutical, food safety, cannabis databases.