EFSA toxicology reference values
Coumarin
Coumarin (CAS 91-64-5). Cannabis testing data across 0 states. Action levels when present, testing requirements, compliance status.
Coumarin is a cannabis analyte contaminant represented in the cannabis public dataset.
Substance Identity
Analyte identity and classification used for this cannabis substance page.
Contaminant Class Badge
Color-coded cannabis class signal for scanning pesticide, metal, solvent, mycotoxin, and potency pages.
Dataset Snapshot
Compact public-data summary for page quality, state coverage, lab rows, and potency sample groups.
EFSA Substance Identity
EFSA substance identity rows matched by chemical name or CAS.
EFSA Reference Values
Reference values from efsa_reference_values_v2 for toxicology and food-safety context.
| Descriptor | Value | Population | Endpoint | Body |
|---|---|---|---|---|
| TDI | - mg/kg bw/day | consumers | c3d80ff5-a23b-4405-927a-fa625d3f3d12 | other: |
| TDI | - mg/kg bw | consumers | c3d80ff5-a23b-4405-927a-fa625d3f3d12 | - |
EFSA Study Results
Endpoint-level study rows from efsa_study_results matched to this substance.
| Endpoint | Species | Route | Effect | Assessment |
|---|---|---|---|---|
| chronic toxicity: other route | dog | - | 10 mg/kg bw/day | - |
| Carcinogenicity_EU_PPP | - | - | - | Coumarin is a naturally occurring flavouring substance. The Scientific Committee for Food (SCF) delivered an opinion on coumarin in 1994 (SCF, 1997) in order that the Commission could consider whether the limits for coumarin in food set out in Annex II of the flavourings Directive 88/388/EEC (EEC, 1988) needed to be amended. The SCF concluded that coumarin was a carcinogen in rats via the oral route and possibly in mice, noting that adenomas and carcinomas of the liver and bile ducts and adenomas of the kidney have been observed in rats and adenomas and carcinomas of the lung and liver adenomas in mice. The Committee noted that a key issue in assessing the risk of coumarin to humans was deciding whether or not coumarin was genotoxic and that particularly strong reassurance was needed that coumarin was not genotoxic in vivo since, in addition to positive results from in vitro genotoxicity studies, an epoxide had been postulated as a metabolic intermediate. |
| Carcinogenicity_EU_PPP | - | - | - | The Panel considered the toxicity studies and the studies on the metabolism of coumarin in humans with CYP2A6 polymorphism that have become available since the last opinion of 2004, as well as clinical studies, and concluded to maintain the TDI of 0.1 mg coumarin/kg bw allocated in the 2004 opinion. |
| Genetic Toxicity | - | - | - | Coumarin is a naturally occurring flavouring substance. The Scientific Committee for Food (SCF) delivered an opinion on coumarin in 1994 (SCF, 1997) in order that the Commission could consider whether the limits for coumarin in food set out in Annex II of the flavourings Directive 88/388/EEC (EEC, 1988) needed to be amended. The SCF concluded that coumarin was a carcinogen in rats via the oral route and possibly in mice, noting that adenomas and carcinomas of the liver and bile ducts and adenomas of the kidney have been observed in rats and adenomas and carcinomas of the lung and liver adenomas in mice. The Committee noted that a key issue in assessing the risk of coumarin to humans was deciding whether or not coumarin was genotoxic and that particularly strong reassurance was needed that coumarin was not genotoxic in vivo since, in addition to positive results from in vitro genotoxicity studies, an epoxide had been postulated as a metabolic intermediate. |
| Genetic Toxicity | - | - | - | The Panel considered the toxicity studies and the studies on the metabolism of coumarin in humans with CYP2A6 polymorphism that have become available since the last opinion of 2004, as well as clinical studies, and concluded to maintain the TDI of 0.1 mg coumarin/kg bw allocated in the 2004 opinion. |
Cross-Reference to Chemicals / Cosmetics / Food
Internal cross-vertical links connecting cannabis rows to chemical, cosmetics, and EFSA food/toxicology context.
Frequently Asked Questions
FAQ answers are generated from the same fetched cannabis, EFSA, cosmetics, and chemical rows rendered above.
What is the regulatory limit for Coumarin in cannabis?
Coumarin does not have a numeric cannabis_contaminant_tests range in the fetched page data. The current page query does not expose a separate action-limit column.
Which states test for Coumarin?
Coumarin does not have state-level cannabis testing rows in the fetched page data.
What are the EFSA reference values for Coumarin?
Coumarin has 2 EFSA OpenFoodTox reference value rows in the cannabis database, including TDI.
Is Coumarin also regulated in cosmetics or food?
Coumarin has a cosmetics ingredient cross-reference with EU status restricted. EFSA food/toxicology context is available on this page.