What is the NOAEL for Dimethicone?
Dimethicone has 100 NOAEL studies in the database. The lowest reported value is 0.125 mg/kg bw/day via oral in Mouse. Source: INCHEM_WHO_jecfa_jecmono_v966je01.
NOAEL Data
Cosmetic Ingredient
Dimethicone
Also known as: Dow Corning 365 Dimethicone NF Emulsion, Dimeticone, Dow Corning 5-7139, Gransil 530, Silicone Fluid 350 (+3 more)
CAS 9006-65-9
Dimethicone (CAS 9006-65-9) is a chemical substance. Key regulatory status: 15 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
15
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
Dimethicone
CAS Number
9006-65-9
DTXSID
DTXSID30897061
Synonyms
Dow Corning 365 Dimethicone NF EmulsionDimeticoneDow Corning 5-7139Gransil 530Silicone Fluid 350Polydimethyl siloxaneDIMETHICONE 350EC No.: 618-433-4
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
DefoamerLubricating agentSoftener and conditionerHumectantSurface modifierProcessing aids not otherwise specified
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
15 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair styling and care - shampoo-dandruff | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe | Danish EPA | Danish EPA |
| Cleaning products and household care; Europe | Danish EPA | Danish EPA |
| Cleaning products and household care; Europe | Danish EPA | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - make-up and related | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| range:0-0.1250.125 | mg/kg bw/day | ADI | oral | Mouse | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-0.1250.125 | mg/kg bw/day | ADI | oral | Mouse | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-0.1250.125 | mg/kg bw/day | ADI | oral | Mouse | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-0.50.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-0.50.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-0.50.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-0.60.6 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-0.60.6 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-0.750.75 | mg/kg bw/day | ADI | oral | Rat | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-0.750.75 | mg/kg bw/day | ADI | oral | Rat | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-0.750.75 | mg/kg bw/day | ADI | oral | Rat | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-0.80.8 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-0.80.8 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-0.80.8 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-11 | mg/kg bw/day | ADI | oral | Rat | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-11 | mg/kg bw/day | ADI | oral | Rat | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-11 | mg/kg bw/day | ADI | oral | Rat | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-1.51.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-1.51.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-1.51.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-2.52.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-2.52.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-2.52.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-44 | mg/kg bw/day | ADI | - | Rat; Mouse | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-44 | mg/kg bw/day | ADI | - | Rat; Mouse | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-44 | mg/kg bw/day | ADI | - | Rat; Mouse | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-55 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-55 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-1010 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-1010 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-12.512.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-12.512.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-12.512.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-2525 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| range:0-2525 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v966je01 |
| 2Y53S6ATLU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2Y53S6ATLU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2Y53S6ATLU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2Y53S6ATLU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5L1VVC3K8O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5L1VVC3K8O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5L1VVC3K8O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5L1VVC3K8O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 92RU3N3Y1O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 92RU3N3Y1O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 92RU3N3Y1O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 92RU3N3Y1O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D1R3R4B8M8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D1R3R4B8M8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D1R3R4B8M8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 50 of 100 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
dimethicone
ChEMBL Phase
Not listed
Adverse Events
2534
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Dimethicone?
Dimethicone appears on 13 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, active_ingredient; animal_products; Europe; pharmaceutical; residue, children; Europe; Personal care, and 10 more. Source: EPA CPDat.
Is Dimethicone used in cosmetics?
Yes, Dimethicone is also indexed as a cosmetic ingredient under the name Dimethicone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dimethicone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Dimethicone used outside industrial chemicals?
Dimethicone also appears in cosmetics, pharmaceutical databases.