Danger GHS07GHS08 NOAEL Data Cosmetic Ingredient

Bromelain, fruit

CAS 9001-00-7

Bromelain, fruit (CAS 9001-00-7) is a chemical substance with GHS signal word Danger; key hazard signal: H335; H315; H319; H334. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for Bromelain →

SOURCE noael studies public
NOAEL studies
12
SOURCE chemical inventory jurisdictions
Regulatory lists
4
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 3 fields
Name
Bromelain, fruit
CAS Number
9001-00-7
DTXSID
DTXSID901010881

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Resp. Sens. 1H335; H315; H319; H334GHS07; GHS08Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 9 records
Softener and conditionerPharmaceuticalFlavouring and nutrientProcessing aids not otherwise specifiedChemical reaction regulatorThickening agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records
ListKeywordSource
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
pharmaceuticalUS International Trade CommissionCPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 12 of 12 studies
ValueUnitEndpointRouteSpeciesSource
F0ZCA6O9QTUNIIFDA UNII substance identifier--openFDA substances
F0ZCA6O9QTUNIIFDA UNII substance identifier--openFDA substances
F0ZCA6O9QTUNIIFDA UNII substance identifier--openFDA substances
F0ZCA6O9QTUNIIFDA UNII substance identifier--openFDA substances
U182GP2CF3UNIIFDA UNII substance identifier--openFDA substances
U182GP2CF3UNIIFDA UNII substance identifier--openFDA substances
U182GP2CF3UNIIFDA UNII substance identifier--openFDA substances
U182GP2CF3UNIIFDA UNII substance identifier--openFDA substances
ZLM4P8929RUNIIFDA UNII substance identifier--openFDA substances
ZLM4P8929RUNIIFDA UNII substance identifier--openFDA substances
ZLM4P8929RUNIIFDA UNII substance identifier--openFDA substances
ZLM4P8929RUNIIFDA UNII substance identifier--openFDA substances

Showing 12 of 12 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
active
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL
ChEMBL Phase
Not listed
Adverse Events
102
Bioactivity
0
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E1101iii — ADI: NOT LIMITED mg/kg bw

View full food safety profile →

Frequently Asked Questions

What is the GHS hazard classification for Bromelain, fruit?

Bromelain, fruit (CAS 9001-00-7) is classified under EU CLP Annex VI as STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Resp. Sens. 1 with signal word Danger. Hazard statements: H335; H315; H319; H334. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Bromelain, fruit?

Bromelain, fruit has 12 NOAEL studies in the database. The lowest reported value is F0ZCA6O9QT UNII. Source: openFDA substances.

What regulatory lists include Bromelain, fruit?

Bromelain, fruit appears on 3 regulatory/inventory lists including Europe; Personal care, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), pharmaceutical. Source: EPA CPDat.

Is Bromelain, fruit used in cosmetics?

Yes, Bromelain, fruit is also indexed as a cosmetic ingredient under the name Bromelain. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Bromelain, fruit come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.

Does Bromelain, fruit have different safety status in cosmetics vs industrial chemicals?

Bromelain, fruit is classified GHS Danger (H335, H315, H319, H334) in the chemicals database but is allowed in EU cosmetics.

Is Bromelain, fruit used outside industrial chemicals?

Bromelain, fruit also appears in cosmetics, pharmaceutical, food safety databases.