Also known as: Caswell No. 856A, m-Cresol, 6-isopropyl-, p-Cymene, 3-hydroxy-, Cymophenol, alpha-, EINECS 201-944-8 (+15 more)
CAS 89-83-8
Thymol (CAS 89-83-8) is a chemical substance with GHS signal word Danger; key hazard signal: H302; H314; H411. Key regulatory status: REACH registered, 37 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Thymol is classified GHS Danger (H302, H314, H411) in the chemicals database but is allowed in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Skin Corr. 1B; Aquatic Chronic 2 | H302; H314; H411 | GHS07; GHS05; GHS09 | Danger |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| agricultural; animal_products; detected; Pesticides; residue | USDA | United States Department of Agriculture (USDA) |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| Pesticides | National Park Service | CPCat |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 34.8793541035235 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 32.4473838912271 | uM | ACC | - | - | NTP_ICE_endocrine |
| =32.9 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =49.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 3J50XA376E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3J50XA376E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3J50XA376E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3J50XA376E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =980 | mg/kg bw | LD50 | oral | Rat (Male/Female) | NTP_ICE_acute_oral |
| =0.1 | mmol | LOEL | injection | Rat | ToxValDB_ECOTOX |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.00465 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =0.25 | mmol | NOEL | injection | Rat | ToxValDB_ECOTOX |
Showing 14 of 14 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Thymol | 201-944-8 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Thymol (CAS 89-83-8) is classified under EU CLP Annex VI as Acute Tox. 4 *; Skin Corr. 1B; Aquatic Chronic 2 with signal word Danger. Hazard statements: H302; H314; H411. Source: EU CLP Annex VI (ECHA).
Thymol has 14 NOAEL studies in the database. The lowest reported value is 32.4473838912271 uM. Source: NTP_ICE_endocrine.
Thymol appears on 15 regulatory/inventory lists including active_ingredient; Pesticides, active_ingredient; Europe; Pesticides, inert_ingredient; non_food_use; Pesticides, and 12 more. Source: EPA CPDat.
Yes, Thymol is also indexed as a cosmetic ingredient under the name Thymol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Thymol is classified GHS Danger (H302, H314, H411) in the chemicals database but is allowed in EU cosmetics.
Thymol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.