What is the NOAEL for Isoascorbic acid?
Isoascorbic acid has 16 NOAEL studies in the database. The lowest reported value is 6 mg/kg bw/day in Consumers. Source: EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Isoascorbic acid
Also known as: D-erythro-Hex-2-enonic acid, .gamma.-lactone, 5-18-05-00026, D-erythro-Ascorbic acid, D-ASCORBIC ACID, ISO, BRN 0084271 (+11 more)
CAS 89-65-6
Isoascorbic acid (CAS 89-65-6) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
16
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
22 fields
Name
Isoascorbic acid
CAS Number
89-65-6
DTXSID
DTXSID6026537
Molecular Formula
C6H8O6
InChI Key
CIWBSHSKHKDKBQ-DUZGATOHSA-N
Monoisotopic Mass
176.032088
Synonyms
D-erythro-Hex-2-enonic acid, .gamma.-lactone5-18-05-00026D-erythro-Ascorbic acidD-ASCORBIC ACID, ISOBRN 0084271EINECS 201-928-0Erythroascorbic acid, D-FEMA No. 2410FEMA Number: 2410Hex-2-enonic acid gamma-lactone, D-erythro-D-erythro-3-Ketohexonic acid lactone3-Keto-D-erythro-hexonic acid gamma-lactone
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
10 records
AntioxidantFragranceChemical reaction regulatorBiocideFlavouring and nutrientDyeFood preservative
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| fracking; water | NY Department of Conservation | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 16 of 16 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =6 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =6 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =70.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 311332OII1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 311332OII1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 311332OII1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 311332OII1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =18000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =650 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =650 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 1000 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 2500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 5000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 7500 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| =2000 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB_ECOTOX |
Showing 16 of 16 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,3-didehydro-D-erythro-hexono-1,4-lactone | 201-928-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL486293
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E315 — ADI: 6 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Isoascorbic acid?
Isoascorbic acid appears on 4 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, animal_products, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is Isoascorbic acid used in cosmetics?
Yes, Isoascorbic acid is also indexed as a cosmetic ingredient under the name Erythorbic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Isoascorbic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Isoascorbic acid used outside industrial chemicals?
Isoascorbic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.