What is the NOAEL for Beta-Caryophyllene?
Beta-Caryophyllene has 12 NOAEL studies in the database. The lowest reported value is BHW853AU9H UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Beta-Caryophyllene
Also known as: Bicyclo[7.2.0]undec-4-ene, 4,11,11-trimethyl-8-methylene-, (1R,4E,9S)-, (-)-(E)-Caryophyllene, (-)-Caryophyllene, Bicyclo(7.2.0)undec-4-ene, 4,11,11-trimethyl-8-methylene-, (1R-(1R*,4E,9S*))-, beta-Caryophyllen (+10 more)
CAS 87-44-5
Beta-Caryophyllene (CAS 87-44-5) is a chemical substance. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Beta-Caryophyllene is classified GHS Danger (H304, H317) in the chemicals database but is restricted in EU cosmetics at max 0.001% leave-on / 0.01% rinse-off (individually declarable above these thresholds under EU Regulation 2023/1545).
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Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
12
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chemical inventory jurisdictions
Regulatory lists
9
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eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
21 fields
Name
Beta-Caryophyllene
CAS Number
87-44-5
DTXSID
DTXSID8024739
Molecular Formula
C15H24
InChI Key
NPNUFJAVOOONJE-GFUGXAQUSA-N
Monoisotopic Mass
204.187801
Synonyms
Bicyclo[7.2.0]undec-4-ene, 4,11,11-trimethyl-8-methylene-, (1R,4E,9S)-(-)-(E)-Caryophyllene(-)-CaryophylleneBicyclo(7.2.0)undec-4-ene, 4,11,11-trimethyl-8-methylene-, (1R-(1R*,4E,9S*))-beta-CaryophyllenCARYOPHYLLENE ,ALPHA + BETA MIXT.EINECS 201-746-1FEMA No. 22522-Methylene-6,10,10-trimethylbicyclo(7.2.0)undec-5-ene8-Methylene-4,11,11-(trimethyl)bicyclo(7.2.0)undec-4-ene4,11,11-Trimethyl-8-methylenebicyclo(7.2.0)undec-4-ene, (1R-(1R*,4E,9S))-UNII-BHW853AU9H
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
60 records
FragranceDeodorizerSoftener and conditionerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
9 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; nondetect; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| BHW853AU9H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BHW853AU9H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BHW853AU9H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BHW853AU9H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =200 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx |
| =200 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx |
| =222 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =222 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =222 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Caryophyllene | 201-746-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
restricted
Max
0.001% leave-on / 0.01% rinse-off (individually declarable above these thresholds under EU Regulation 2023/1545)
Category
fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
BETA-CARYOPHYLLENE
ChEMBL Phase
1
Adverse Events
0
Bioactivity
5
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
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EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Beta-Caryophyllene?
Beta-Caryophyllene appears on 8 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 5 more. Source: EPA CPDat.
Is Beta-Caryophyllene used in cosmetics?
Yes, Beta-Caryophyllene is also indexed as a cosmetic ingredient under the name Beta-Caryophyllene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Beta-Caryophyllene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Beta-Caryophyllene have different safety status in cosmetics vs industrial chemicals?
Beta-Caryophyllene is classified GHS Danger (H304, H317) in the chemicals database but is restricted in EU cosmetics at max 0.001% leave-on / 0.01% rinse-off (individually declarable above these thresholds under EU Regulation 2023/1545).
Is Beta-Caryophyllene used outside industrial chemicals?
Beta-Caryophyllene also appears in cosmetics, pharmaceutical, food safety, cannabis databases.