EFSA toxicology reference values
beta-Caryophyllene
SOURCE
efsa openfoodtox 3 0 export repository
beta-Caryophyllene (CAS 87-44-5). Cannabis testing data across 0 states. Action levels when present, testing requirements, compliance status.
beta-Caryophyllene is a cannabis analyte contaminant represented in the cannabis public dataset.
CAS 87-44-5
Cannabis Analyte
Substance Identity
Analyte identity and classification used for this cannabis substance page.
SOURCE
efsa substances
Analyte name
beta-Caryophyllene
CAS number
87-44-5
Contaminant class
Cannabis Analyte
Contaminant Class Badge
Color-coded cannabis class signal for scanning pesticide, metal, solvent, mycotoxin, and potency pages.
SOURCE
State Cannabis Regulations
Cannabis Analyte
Cannabis contaminant class used to group state testing rows.
Dataset Snapshot
Compact public-data summary for page quality, state coverage, lab rows, and potency sample groups.
SOURCE
cannabis page data
Quality score
2
thin
Jurisdictions
0
No state rows
Lab/analyte rows
0
0 failed (-)
Potency samples
0
87-44-5
EFSA Substance Identity
EFSA substance identity rows matched by chemical name or CAS.
SOURCE
efsa openfoodtox 3 0 export repository
beta-Caryophyllene
CAS 87-44-5 / mono-constituent substance
C15H24 / 4 dossier(s)
EFSA Reference Values
Reference values from efsa_reference_values_v2 for toxicology and food-safety context.
SOURCE
efsa openfoodtox 3 0 export repository
| Descriptor | Value | Population | Endpoint | Body |
|---|---|---|---|---|
| MSI/FC | 5 mg/kg | other: | - | - |
| MSI/FC | 5 mg/kg | other: | e1da0bc5-431d-4997-ab9c-bc8bcadcf358 | - |
| MSI/FC | 5 mg/kg | other: | e1da0bc5-431d-4997-ab9c-bc8bcadcf358 | - |
| MSI/FC | 5 mg/kg | other: | e1da0bc5-431d-4997-ab9c-bc8bcadcf358 | - |
| MSI/FC | 5 mg/kg | other: | e1da0bc5-431d-4997-ab9c-bc8bcadcf358 | - |
| MSI/FC | 5 mg/kg | other: | - | - |
| MSI/FC | 5 mg/kg | other: | - | - |
| MSI/FC | 5 mg/kg | other: | - | - |
| TTC Cramer Class I | 30 µg/kg bw/day | consumers | - | - |
| TTC Cramer Class I | 30 µg/kg bw/day | consumers | - | - |
| TTC Cramer Class I | 30 µg/kg bw/day | consumers | - | - |
| margin of safety | 40,000 other: | consumers | e1da0bc5-431d-4997-ab9c-bc8bcadcf358 | - |
EFSA Study Results
Endpoint-level study rows from efsa_study_results matched to this substance.
SOURCE
efsa openfoodtox 3 0 export repository
| Endpoint | Species | Route | Effect | Assessment |
|---|---|---|---|---|
| sub-chronic toxicity: oral | rat | oral: feed | 222 other: | - |
| in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus | mouse | not specified | - | In compliance with OECD 474 -except: number of micronucleated immature erythrocytes not given separately for each animal; historical controls not given. Reliable with restrictions=limited validity. Study: Molina, Jasso et al. 2009 |
| Carcinogenicity_EU_PPP | - | - | - | The Scientific Panel on Food Food Contact Materials, Enzymes, Flavourings and Processing Aids (the Panel) was asked to provide scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the Panel was requested to consider the Joint FAO/WHO Expert Committee on Food Additives (the JECFA) evaluations of flavouring substances assessed since 2000, and to decide whether no further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. These flavouring substances are listed in the Register, which was adopted by Commission Decision 1999/217 EC and its consecutive amendments. The present consideration concerns 24 aliphatic, alicyclic and aromatic hydrocarbons evaluated by the JECFA (65th meeting). The Panel concluded that the 24 substances are structurally related to the group of 37 aliphatic and aromatic hydrocarbons evaluated by EFSA in the Flavouring Group Evaluation 25, Revision 2 (FGE.25Rev2). |
| Carcinogenicity_EU_PPP | - | - | - | The European Commission received a request from Feed Flavourings Authorisation Consortium European Economic Interest Grouping (FFAC EEIG) for authorisation of 17 substances belonging to chemical group 31, when used as a feed additive for all animal species (category: sensory additives; functional group: flavourings). Chemical group (CG) 31 for flavouring substances is defined in Commission Regulation (EC) No 1565/20004 as 'aliphatic and aromatic hydrocarbons'. According to Article 7(1) of Regulation (EC) No 1831/2003, the Commission forwarded the application to EFSA as an application under Article 4(1) (authorisation of a feed additive or new use of a feed additive) and under Article 10(2) (re-evaluation of an authorised feed additive). EFSA received directly from the applicant the technical dossier in support of this application. The particulars and documents in support of the application were considered valid by EFSA as of 9 June 2010. According to Article 8 of Regulation (EC) No 1831/2003, EFSA shall undertake an assessment in order to determine whether the feed additive complies with the conditions laid down in Article 5. EFSA shall deliver an opinion on the safety for the target animals, consumer, user and the environment and on the efficacy of the pin-2(10)-ene, pin-2(3)-ene, beta-caryophyllene, myrcene, camphene, valencene, beta-ocimene and delta-3-carene, when used under the proposed conditions of use. |
| Carcinogenicity_EU_PPP | - | - | - | Following a request from the European Commission the EFSA CEF Panel was asked to deliver scientific opinion on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the CEF Panel was requested to consider the Joint FAO/WHO Expert Committee on Food Additives (the JECFA) evaluations of flavouring substances assessed since 2000, and to decide whether no further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. These flavouring substances are listed in the Register, which was adopted by Commission Decision 1999/217/EC and its consecutive amendments. The present revision of FGE.78, FGE.78Rev2, includes the assessment of additional available toxicity data for beta-caryophyllene [FL-no: 01.007] and myrcene [FL-no: 01.008]. The data provided are for both substances a new 90-day study. Furthermore, new short term study and genotoxicity data have been provided for [FL-no: 01.007]. In addition, since the publication of FGE.78Rev1, two ([FL-no: 01.011 and 01.013]) of the 24 substances are no longer supported for use as flavouring substances in Europe by Industry. Moreover, [FL-no: 01.014] is in the process of being deleted from the Union List. Accordingly, FGE.78Rev2 only deals with 21 substances. |
| Carcinogenicity_EU_PPP | - | - | - | The Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (the Panel) is asked to advise the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular the Scientific Panel is requested to consider the Joint FAO/WHO Expert Committee on Food Additives (the JECFA) evaluations of flavouring substances assessed since 2000, and to decide whether no further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. These flavouring substances are listed in the Register, which was adopted by Commission Decision 1999/217/EC, and its consecutive amendments. The present consideration deals with 24 aliphatic, alicyclic and aromatic hydrocarbons evaluated by the JECFA at their 63rd meeting. The Panel concluded that the 24 substances in the JECFA flavouring are structurally related to the group of 32 aliphatic and aromatic hydrocarbons evaluated by the European Food Safety Authority (EFSA) in the Flavouring Group Evaluation 25 (FGE.25). |
| Genetic Toxicity | - | - | - | Following a request from the European Commission the EFSA CEF Panel was asked to deliver scientific opinion on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the CEF Panel was requested to consider the Joint FAO/WHO Expert Committee on Food Additives (the JECFA) evaluations of flavouring substances assessed since 2000, and to decide whether no further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. These flavouring substances are listed in the Register, which was adopted by Commission Decision 1999/217/EC and its consecutive amendments. The present revision of FGE.78, FGE.78Rev2, includes the assessment of additional available toxicity data for beta-caryophyllene [FL-no: 01.007] and myrcene [FL-no: 01.008]. The data provided are for both substances a new 90-day study. Furthermore, new short term study and genotoxicity data have been provided for [FL-no: 01.007]. In addition, since the publication of FGE.78Rev1, two ([FL-no: 01.011 and 01.013]) of the 24 substances are no longer supported for use as flavouring substances in Europe by Industry. Moreover, [FL-no: 01.014] is in the process of being deleted from the Union List. Accordingly, FGE.78Rev2 only deals with 21 substances. |
| Genetic Toxicity | - | - | - | The European Commission received a request from Feed Flavourings Authorisation Consortium European Economic Interest Grouping (FFAC EEIG) for authorisation of 17 substances belonging to chemical group 31, when used as a feed additive for all animal species (category: sensory additives; functional group: flavourings). Chemical group (CG) 31 for flavouring substances is defined in Commission Regulation (EC) No 1565/20004 as 'aliphatic and aromatic hydrocarbons'. According to Article 7(1) of Regulation (EC) No 1831/2003, the Commission forwarded the application to EFSA as an application under Article 4(1) (authorisation of a feed additive or new use of a feed additive) and under Article 10(2) (re-evaluation of an authorised feed additive). EFSA received directly from the applicant the technical dossier in support of this application. The particulars and documents in support of the application were considered valid by EFSA as of 9 June 2010. According to Article 8 of Regulation (EC) No 1831/2003, EFSA shall undertake an assessment in order to determine whether the feed additive complies with the conditions laid down in Article 5. EFSA shall deliver an opinion on the safety for the target animals, consumer, user and the environment and on the efficacy of the pin-2(10)-ene, pin-2(3)-ene, beta-caryophyllene, myrcene, camphene, valencene, beta-ocimene and delta-3-carene, when used under the proposed conditions of use. |
| Genetic Toxicity | - | - | - | The Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (the Panel) is asked to advise the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular the Scientific Panel is requested to consider the Joint FAO/WHO Expert Committee on Food Additives (the JECFA) evaluations of flavouring substances assessed since 2000, and to decide whether no further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. These flavouring substances are listed in the Register, which was adopted by Commission Decision 1999/217/EC, and its consecutive amendments. The present consideration deals with 24 aliphatic, alicyclic and aromatic hydrocarbons evaluated by the JECFA at their 63rd meeting. The Panel concluded that the 24 substances in the JECFA flavouring are structurally related to the group of 32 aliphatic and aromatic hydrocarbons evaluated by the European Food Safety Authority (EFSA) in the Flavouring Group Evaluation 25 (FGE.25). |
| Genetic Toxicity | - | - | - | The Scientific Panel on Food Food Contact Materials, Enzymes, Flavourings and Processing Aids (the Panel) was asked to provide scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the Panel was requested to consider the Joint FAO/WHO Expert Committee on Food Additives (the JECFA) evaluations of flavouring substances assessed since 2000, and to decide whether no further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. These flavouring substances are listed in the Register, which was adopted by Commission Decision 1999/217 EC and its consecutive amendments. The present consideration concerns 24 aliphatic, alicyclic and aromatic hydrocarbons evaluated by the JECFA (65th meeting). The Panel concluded that the 24 substances are structurally related to the group of 37 aliphatic and aromatic hydrocarbons evaluated by EFSA in the Flavouring Group Evaluation 25, Revision 2 (FGE.25Rev2). |
Cross-Reference to Chemicals / Cosmetics / Food
Internal cross-vertical links connecting cannabis rows to chemical, cosmetics, and EFSA food/toxicology context.
SOURCE
core public cross-reference
Frequently Asked Questions
FAQ answers are generated from the same fetched cannabis, EFSA, cosmetics, and chemical rows rendered above.
SOURCE
page FAQ dataset
What is the regulatory limit for beta-Caryophyllene in cannabis?
beta-Caryophyllene does not have a numeric cannabis_contaminant_tests range in the fetched page data. The current page query does not expose a separate action-limit column.
Which states test for beta-Caryophyllene?
beta-Caryophyllene does not have state-level cannabis testing rows in the fetched page data.
What are the EFSA reference values for beta-Caryophyllene?
beta-Caryophyllene has 15 EFSA OpenFoodTox reference value rows in the cannabis database, including MSI/FC, TTC Cramer Class I, margin of safety, Incomplete dataset.
Is beta-Caryophyllene also regulated in cosmetics or food?
beta-Caryophyllene has a cosmetics ingredient cross-reference with EU status restricted. EFSA food/toxicology context is available on this page.