NOAEL Data Cosmetic Ingredient

8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol, 3-nitrate

Also known as: Nipradilol, 2H-1-Benzopyran-3-ol, 3,4-dihydro-8-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, 3-nitrate, 8-{2-Hydroxy-3-[(propan-2-yl)amino]propoxy}-3,4-dihydro-2H-1-benzopyran-3-yl nitrate

CAS 81486-22-8

8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol, 3-nitrate (CAS 81486-22-8) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.

View cosmetic safety profile for NIPRADILOL →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 9 fields

Name

8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol, 3-nitrate

CAS Number

81486-22-8

DTXSID

DTXSID30868615

Molecular Formula

C15H22N2O6

InChI Key

OMCPLEZZPVJJIS-UHFFFAOYSA-N

Monoisotopic Mass

326.147786

Synonyms

Nipradilol2H-1-Benzopyran-3-ol, 3,4-dihydro-8-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, 3-nitrate8-{2-Hydroxy-3-[(propan-2-yl)amino]propoxy}-3,4-dihydro-2H-1-benzopyran-3-yl nitrate

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records

Softener and conditioner

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records

List	Keyword	Source
pharmaceutical	US International Trade Commission	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 5 of 5 studies

Value	Unit	Endpoint	Route	Species	Source
FVM336I71Y	UNII	FDA UNII substance identifier	-	-	openFDA substances
FVM336I71Y	UNII	FDA UNII substance identifier	-	-	openFDA substances
FVM336I71Y	UNII	FDA UNII substance identifier	-	-	openFDA substances
FVM336I71Y	UNII	FDA UNII substance identifier	-	-	openFDA substances
=1040	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral

Showing 5 of 5 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL NIPRADILOL

ChEMBL Phase

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol, 3-nitrate?

8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol, 3-nitrate has 5 NOAEL studies in the database. The lowest reported value is FVM336I71Y UNII. Source: openFDA substances.

What regulatory lists include 8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol, 3-nitrate?

8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol, 3-nitrate appears on 1 regulatory/inventory list including pharmaceutical. Source: EPA CPDat.

Is 8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol, 3-nitrate used in cosmetics?

Yes, 8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol, 3-nitrate is also indexed as a cosmetic ingredient under the name NIPRADILOL. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol, 3-nitrate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol, 3-nitrate used outside industrial chemicals?

8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol, 3-nitrate also appears in cosmetics, pharmaceutical databases.