NOAEL Data REACH Registered Cosmetic Ingredient

Caramel

Also known as: (Caramel) (AP 680) (BC 420 (Color)) (Burnt sugar) (Burnt sugar coloring), BC 420, Burnt sugar, Burnt sugar coloring, Caramel flavor (+6 more)

CAS 8028-89-5

Caramel (CAS 8028-89-5) is a chemical substance. Key regulatory status: REACH registered, 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Caramel →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 14 fields

Name

Caramel

CAS Number

8028-89-5

DTXSID

DTXSID2044264

Synonyms

(Caramel) (AP 680) (BC 420 (Color)) (Burnt sugar) (Burnt sugar coloring)BC 420Burnt sugarBurnt sugar coloringCaramel flavorCaramel liquidEINECS 232-435-9FEMA No. 2235Natural brown 10UNII-T9D99G2B1RCaramel (color)

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

DyeDeodorizerFragrancePigmentTracer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 10 records

List	Keyword	Source
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List
inert_ingredient; Pesticides	EPA	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
general_foods	FDA	United States Food and Drug Administration (FDA)
pharmaceutical	FDA	United States Food and Drug Administration (FDA)
Personal care	FDA	United States Food and Drug Administration (FDA)
Europe; Personal care	European Commission	CosIng
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
IFRA Transparency	IFRA	IFRA
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 23 of 23 studies

Value	Unit	Endpoint	Route	Species	Source
=100	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=100	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
<=160	mg/kg	ADI	oral	Human	ToxValDB_WHO_JECFA_ADI
<=200	mg/kg	ADI	oral	Human	ToxValDB_WHO_JECFA_ADI
=300	mg/kg bw/day	ADI (group)	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=300	mg/kg bw/day	ADI (group)	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
T9D99G2B1R	UNII	FDA UNII substance identifier	-	-	openFDA substances
T9D99G2B1R	UNII	FDA UNII substance identifier	-	-	openFDA substances
T9D99G2B1R	UNII	FDA UNII substance identifier	-	-	openFDA substances
T9D99G2B1R	UNII	FDA UNII substance identifier	-	-	openFDA substances
=10	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=15	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=20	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=20	g/kg bw/day	NOAEL	-	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=20	g/kg bw/day	NOAEL	-	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>=25	g/kg bw/day	NOAEL	oral: drinking water	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>=25	g/kg bw/day	NOAEL	oral: drinking water	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=30	g/kg bw/day	NOAEL	oral: drinking water	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=30	g/kg bw/day	NOAEL	oral: drinking water	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
100	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
400	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
500	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=20000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA

Showing 23 of 23 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Caramel (color)	232-435-9	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E150a — 1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Caramel?

Caramel has 23 NOAEL studies in the database. The lowest reported value is 100 mg/kg bw/day in Consumers. Source: EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx.

What regulatory lists include Caramel?

Caramel appears on 9 regulatory/inventory lists including SCIL (9/2019), inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, and 6 more. Source: EPA CPDat.

Is Caramel used in cosmetics?

Yes, Caramel is also indexed as a cosmetic ingredient under the name Caramel. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Caramel come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Caramel used outside industrial chemicals?

Caramel also appears in cosmetics, food safety, cannabis databases.