What is the GHS hazard classification for Citric acid?
Citric acid (CAS 77-92-9) is classified under EU CLP Annex VI as STOT SE 3; Eye Irrit. 2 with signal word Warning. Hazard statements: H335; H319. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Citric acid
Also known as: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, 4-03-00-01272, BRN 0782061, Caswell No. 221C, Citric acid, anhydrous (+15 more)
CAS 77-92-9
Citric acid (CAS 77-92-9) is a chemical substance with GHS signal word Warning; key hazard signal: H335; H319. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
46
SOURCE
chemical inventory jurisdictions
Regulatory lists
60
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Citric acid
CAS Number
77-92-9
DTXSID
DTXSID3020332
Molecular Formula
C6H8O7
InChI Key
KRKNYBCHXYNGOX-UHFFFAOYSA-N
Monoisotopic Mass
192.027003
Synonyms
1,2,3-Propanetricarboxylic acid, 2-hydroxy-4-03-00-01272BRN 0782061Caswell No. 221CCitric acid, anhydrousEINECS 201-069-1EPA Pesticide Chemical Code 021801FEMA No. 2306FEMA Number 23062-Hydroxypropanetricarboxylic acid2-Hydroxytricarballylic acidKyselina 2-hydroxy-1,2,3-propantrikarbonova
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| STOT SE 3; Eye Irrit. 2 | H335; H319 | GHS07 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. |
| Long-term Effects | The substance may have effects on the teeth. This may result in erosion. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Chelating agentpH regulating agentPreservativeStabilizing agentDeodorizerBiocide
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
60 records
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| Cleaning products and household care - oven - oven cleaner; Europe | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 46 of 46 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 9.09 | min | Breakthrough Time | Dermal | - | NTP_ICE_skin_irritation |
| GQH5A01T0W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GQH5A01T0W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GQH5A01T0W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GQH5A01T0W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XF417D3PSL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XF417D3PSL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XF417D3PSL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XF417D3PSL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 0.2 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| =3000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =6730 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| <11700 | mg/kg bw | LD50 | oral | Rat (Male/Female) | NTP_ICE_acute_oral |
| >=31100 | mg/m3 | LEL | inhalation | Guinea Pig | ToxValDB_ECHA_IUCLID |
| ~75000 | mg/m3 | LEL | inhalation | Guinea Pig | ToxValDB_ECHA_IUCLID |
| <=81000 | mg/m3 | LEL | inhalation | Guinea Pig | ToxValDB_ECHA_IUCLID |
| =2000 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =8000 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =4 | % | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =15 | % | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =100 | mg/kg bw/day | LOEL | injection | Mouse | ToxValDB_ECOTOX |
| =124 | mg/L | LOEL | oral | Mouse | ToxValDB_ECOTOX |
| =3000 | mg/kg bw/day | LOEL | injection | Rat | ToxValDB_ECOTOX |
| 30 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| >241 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =250 | mg/kg bw/day | NOAEL | injection | Rat | ToxValDB_ECHA_IUCLID |
| >272 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| >295 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >425 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =1200 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=2500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =4000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =5 | % | NOEL | oral | Mouse | ToxValDB_ECOTOX |
| 15.7 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
| 3.3 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 4.1 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 4.5 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 79.4 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 84.6 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 95.4 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 1.6 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 19.3 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 32.4 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
Showing 46 of 46 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Citric acid | 201-069-1 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
pH-adjuster
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CITRIC ACID
ChEMBL Phase
4
Adverse Events
20
Bioactivity
8
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E330 — ADI: NOT LIMITED mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Citric acid?
Citric acid has 46 NOAEL studies in the database. The lowest reported value is 9.09 min via Dermal. Source: NTP_ICE_skin_irritation.
What regulatory lists include Citric acid?
Citric acid appears on 22 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, active_ingredient; Pesticides, inert_ingredient; Pesticides, and 19 more. Source: EPA CPDat.
Is Citric acid used in cosmetics?
Yes, Citric acid is also indexed as a cosmetic ingredient under the name Citric Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Citric acid come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Citric acid used outside industrial chemicals?
Citric acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.