OralTopicalDosed ingredient Cosmetic cross-reference

Citric Acid

CAS 77-92-9

Citric Acid (CAS 77-92-9) is a Phase 4 pharmaceutical compound with 2 bioactivity targets and 20 adverse event associations.

SOURCE NLM DailyMed

Label records

SOURCE EMBL-EBI ChEMBL

Bioactivity

SOURCE DrugCentral

Adverse signals

SOURCE IUPHAR/BPS

PubMed IDs

SOURCE EMBL-EBI ChEMBL B25820EEF0F0

Compound Identity

Matched identifiers and naming fields for the pharmaceutical compound record.

Primary Name

Citric Acid

CAS Number

77-92-9

UNII

XF417D3PSL

InChIKey

KRKNYBCHXYNGOX-UHFFFAOYSA-N

ChEMBL ID

CHEMBL1261

Molecule Type

Small molecule

Source Match

EMBL-EBI ChEMBL (INCHIKEY)

Synonyms and normalized names

anhydrous Citric AcidCITRIC ACID ANHYDROUS

dosed ingredientnatural productoraltopical

SOURCE EMBL-EBI ChEMBL B25820EEF0F0

Clinical Development Phase

Highest clinical development phase rendered from the matched compound identifier rows.

Phase 4 (Approved)

Approved or marketed human pharmaceutical use is represented in the source phase field.

ChEMBL CHEMBL1261 | Small molecule

SOURCE Ingredients table / CosIng profile same-CAS cross-reference

Cross-Reference to Cosmetics

Same-CAS ingredient record found in the cosmetics vertical.

This substance also has a cosmetic safety profile →

SOURCE EMBL-EBI ChEMBL 8 bioactivity rows

Bioactivity & Target Interactions

Target-level activity records with assay counts, activity type, and measured value where present.

Target	Activity	Value	Assays	Organism
-	AC50	30000 nM	30	-
-	Potency	38192.555555555555 nM	17	-
-	IC50	13188.5 nM	4	-
-	Kd	4900 nM	2	-
-	EC50	0.074 ug.mL-1	1	-
3-dehydroquinate dehydratase Enzyme	Kd	5.6	-	Helicobacter pylori (strain ATCC 700392 / 26695)
3-dehydroquinate dehydratase Enzyme	Kd	5.14	-	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Transient receptor potential cation channel subfamily V member 4 Ion channel	EC50	5.6	-	Mus musculus

SOURCE DrugCentral 19 associations

Adverse Event Associations

DrugCentral / FAERS disproportionality signal rows matched to this compound.

Reaction PT	Drug AE	LLR	MedDRA
Appendicolith	21	62.741	10074458
Toxic epidermal necrolysis	33	58.703	10044223
Blood phosphorus increased	20	53.932	10050196
Appendicitis	21	42.324	10003011
Myasthenia gravis	16	38.597	10028417
Abdominal distension	38	35.003	10000060
Ventricular fibrillation	21	34.65	10047290
Blood uric acid increased	16	34.435	10005861
Cardiogenic shock	21	29.956	10007625
Drug hypersensitivity	59	27.761	10013700
Stress	27	26.048	10042209
Dry mouth	27	23.17	10013781
Analgesic therapy	6	22.757	10053469
Sleep disorder therapy	6	22.634	10040990
Drug therapy	6	21.671	10063370
Hyperphosphataemia	9	21.274	10020711
Neuralgia	16	19.781	10029223
Ascites	22	18.838	10003445
Thrombosis	24	17.617	10043607

Association rows are source-linked signal records, not incidence rates or clinical causality claims.

SOURCE IUPHAR/BPS 2 interactions

IUPHAR Ligand-Target Data

Curated ligand-target interaction rows with action, affinity, and literature identifiers.

Target	Action	Affinity	PubMed
TRPP2 PKD2L1	Agonist	1.7 pEC50	16891422
TRPV4 Trpv4	Agonist	5.6 pEC50	12692122

SOURCE NLM RxNorm 10 name rows

Drug Names / RxNorm

Normalized drug-name vocabulary rows, RxCUIs, and source abbreviations.

Name	RxCUI	Type	Source
Citric Acid	21183	SU	MTHSPL
citric acid	21183	SU	MTHSPL
CITRIC ACID	21183	SU	MTHSPL
anhydrous Citric Acid	221946	SU	MTHSPL
Anhydrous Citric Acid	221946	SU	MTHSPL
ANHYDROUS CITRIC ACID	221946	SU	MTHSPL
Anhydrous citric acid	221946	SU	MTHSPL
CITRIC ACID ANHYDROUS	221946	SU	MTHSPL
anhydrous citric acid	221946	SU	MTHSPL
citric acid	21183	IN	RXNORM

SOURCE SIDER 53 side-effect rows

Side Effects

SIDER side-effect terms mapped to the drug or same-CAS compound identity.

Side Effect	Drug Name	MedDRA Type	Concept ID
Abdominal discomfort	citric	LLT	C0232487
Abdominal discomfort	citric	PT	C0232487
Abdominal discomfort	citric	PT	C0232487
Abdominal pain upper	citric	PT	C0232492
Apathy	citric	LLT	C0085632
Apathy	citric	PT	C0085632
Asthenia	citric	LLT	C0004093
Asthenia	citric	PT	C0004093
Blood calcium decreased	citric	PT	C3665624
Calcium low	citric	LLT	C0860967
Chills	citric	LLT	C0085593
Chills	citric	PT	C0085593
Citrate toxicity	citric	LLT	C0948342
Citrate toxicity	citric	PT	C0948342
Confusional state	citric	LLT	C0009676
Confusional state	citric	PT	C0009676
Diarrhoea	citric	LLT	C0011991
Diarrhoea	citric	PT	C0011991
Diarrhoea	citric	PT	C0011991
Dysarthria	citric	PT	C0013362
Electrocardiogram QRS complex	citric	PT	C0429098
Electrocardiogram ST segment	citric	LLT	C0429029
Electrocardiogram ST segment	citric	PT	C0429029
Electrocardiogram abnormal	citric	LLT	C0522055
Electrocardiogram abnormal	citric	PT	C0522055
Feeling abnormal	citric	PT	C1443060
Flat affect	citric	PT	C0233471
Gastrointestinal tract irritation	citric	LLT	C2697368
Gastrointestinal tract irritation	citric	PT	C2697368
Hepatic impairment	citric	LLT	C0948807
Hyperkalaemia	citric	LLT	C0020461
Hyperkalaemia	citric	PT	C0020461
Hypocalcaemia	citric	LLT	C0020598
Hypocalcaemia	citric	PT	C0020598
Hypotension	citric	LLT	C0020649
Hypotension	citric	PT	C0020649
Intoxication	citric	LLT	C0728899
Liver disorder	citric	PT	C0023895
Loose stools	citric	LLT	C2129214
Nausea	citric	LLT	C0027497
Nausea	citric	PT	C0027497
Paraesthesia	citric	LLT	C0030554
Paraesthesia	citric	PT	C0030554
Paraesthesia	citric	PT	C0030554
Paraesthesia	citric	PT	C0030554
Poisoning	citric	PT	C0032343
QRS complex	citric	LLT	C0429097
Slurred speech	citric	LLT	C0234518
Stomach cramps	citric	LLT	C0344375
Tingling of extremity	citric	LLT	C1504494
Tingling sensation	citric	LLT	C2242996
Vomiting	citric	LLT	C0042963
Vomiting	citric	PT	C0042963

SOURCE Rendered pharma page rows FAQPage JSON-LD

Frequently Asked Questions

Short answers generated only from the same visible source-linked rows on this page.

What is Citric Acid used for in pharmaceutical contexts?

Citric Acid (CAS 77-92-9) is rendered as a pharmaceutical compound from the matched source rows; no DailyMed product-name rows are present in this page query.

What are the known adverse events for Citric Acid?

Citric Acid has 20 DrugCentral/FAERS adverse event associations. Rendered reaction terms include Appendicolith, Toxic epidermal necrolysis, Blood phosphorus increased, Appendicitis, Myasthenia gravis. Signal rows are source-linked records and should not be read as incidence rates or causality conclusions.

Is Citric Acid also used in cosmetics?

Yes. The ingredients table has a same-CAS cosmetic profile for Citric Acid with EU status "permitted".

What clinical phase is Citric Acid in?

Citric Acid is rendered with ChEMBL max phase 4 (approved).

What bioactivity targets are documented for Citric Acid?

Citric Acid has 8 bioactivity rows in this page query. Rendered target entries include 3-dehydroquinate dehydratase, Transient receptor potential cation channel subfamily V member 4.