NOAEL Data Cosmetic Ingredient

Natamycin

Also known as: δ-Natamycin, [1R-(1R*,3S*,5R*,7R*,8E,12R*,14E,16E,18E,20E,22R*,24S*,25R*,26S*)]-22-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid, natamycine, natamicina, Acido 6,11,28-trioxatriciclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaeno-25-carboxilico, 22-[(3-amino-3,6-dideoxi-β-d-manopiranosil)oxi]-1,3,26-trihidroxi-12-metil-10-oxo-, (1r,3s,5r,7r,8e,12r,14e,16e,18e,20e,22r,24s,25r,26s)- (+11 more)

CAS 7681-93-8

Natamycin (CAS 7681-93-8) is a chemical substance. Key regulatory status: 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.

View cosmetic safety profile for NATAMYCIN →

SOURCE noael studies public
NOAEL studies
26
SOURCE chemical inventory jurisdictions
Regulatory lists
5
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 22 fields
Name
Natamycin
CAS Number
7681-93-8
DTXSID
DTXSID6021163
Molecular Formula
C33H47NO13
InChI Key
NCXMLFZGDNKEPB-FFPOYIOWSA-N
Monoisotopic Mass
665.304741
Synonyms
δ-Natamycin[1R-(1R*,3S*,5R*,7R*,8E,12R*,14E,16E,18E,20E,22R*,24S*,25R*,26S*)]-22-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acidnatamycinenatamicinaAcido 6,11,28-trioxatriciclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaeno-25-carboxilico, 22-[(3-amino-3,6-dideoxi-β-d-manopiranosil)oxi]-1,3,26-trihidroxi-12-metil-10-oxo-, (1r,3s,5r,7r,8e,12r,14e,16e,18e,20e,22r,24s,25r,26s)-PimaricinAntibiotic A-5283DelvolanDelvoposEINECS 231-683-5Pimaricine16-(3-Amino-3,6-didesoxy-beta-D-mannopyranosyloxy)-5,6-epoxy-8,12,14-trihydroxy-26-methyl-2,10-dioxo-1-oxacyclohexacosa-3,17,19,21,23-pentaen-13-carbonsaeure

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records
BiocidePreservative

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records
ListKeywordSource
active_ingredient; PesticidesCalifornia Department of Pesticide RegulationState of California
pharmaceuticalUS International Trade CommissionCPCat
active_ingredient; animal_products; Europe; pharmaceutical; residueEUCPCat
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
Canada; pharmaceuticalDrugBankDrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 26 of 26 studies
ValueUnitEndpointRouteSpeciesSource
<=0.3mg/kgADIoralHumanToxValDB_WHO_JECFA_ADI
8O0C852CPOUNIIFDA UNII substance identifier--openFDA substances
8O0C852CPOUNIIFDA UNII substance identifier--openFDA substances
8O0C852CPOUNIIFDA UNII substance identifier--openFDA substances
8O0C852CPOUNIIFDA UNII substance identifier--openFDA substances
=2730mg/kg bwLD50oralRatNTP_ICE_acute_oral
=5mg/kg bw/dayLOELinjectionRatToxValDB_ECOTOX
=7mg/kg bw/dayLOELoralDogToxValDB_ECOTOX
=200mg/kg bw/dayLOELoralRatToxValDB_ECOTOX
=400mg/kg bw/dayLOELoralRatToxValDB_ECOTOX
=6.25mg/kg bw/dayNOAELoralDogToxValDB_EFSA
=6.25mg/kg bw/dayNOAELoral: feedDogEFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=6.25mg/kg bw/dayNOAELoral: feedDogEFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
15mg/kg bw/dayNOAELoraldogCOSMOS_DB
=22.4mg/kg bw/dayNOAELoralRatToxValDB_EFSA
=22.4mg/kg bw/dayNOAELoral: feedRatEFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=22.4mg/kg bw/dayNOAELoral: feedRatEFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
40mg/kg bw/dayNOAELoralratCOSMOS_DB
50mg/kg bw/dayNOAELoralratCOSMOS_DB
100mg/kg bw/dayNOAELoralratCOSMOS_DB
=1mg/kg bw/dayNOELinjectionRatToxValDB_ECOTOX
=10mg/kg bw/dayNOELinjectionRatToxValDB_ECOTOX
=100mg/kg bw/dayNOELoralRatToxValDB_ECOTOX
=170mg/kg bw/dayNOELoralRatToxValDB_ECOTOX
=200mg/kg bw/dayNOELoralRatToxValDB_ECOTOX
=300mg/kg bw/dayNOELoralRatToxValDB_ECOTOX

Showing 26 of 26 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Preservatives
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL NATAMYCIN
ChEMBL Phase
4
Adverse Events
393
Bioactivity
1
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 2 records

E235 — ADI: 0.3 mg/kg bw | FDA GRAS: FDA has no questions

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Natamycin?

Natamycin has 26 NOAEL studies in the database. The lowest reported value is 0.3 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.

What regulatory lists include Natamycin?

Natamycin appears on 5 regulatory/inventory lists including active_ingredient; Pesticides, pharmaceutical, active_ingredient; animal_products; Europe; pharmaceutical; residue, and 2 more. Source: EPA CPDat.

Is Natamycin used in cosmetics?

Yes, Natamycin is also indexed as a cosmetic ingredient under the name NATAMYCIN. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Natamycin come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Natamycin used outside industrial chemicals?

Natamycin also appears in cosmetics, pharmaceutical, food safety, cannabis databases.