Food Safety Substance
NatamycinE235
Natamycin (E235) is a food additive with PUBLISHED in the EU, FDA has no questions in the US, and data from 9 regulatory sources.
CAS 7681-93-8
E235
Indexable evidence set
FDA
FDA has no questions
ADI / TDI
ADI 0-0.3 mg/kg bw (1976)
Codex
8 row(s)
SOURCE
D1 identity resolution
e number aliases | Food Additives | dsstox identifiers | 9 matched regulatory source group(s)
Substance Identity
Resolved identifiers used to render this food-safety record.
Substance name
Natamycin
CAS
7681-93-8
E-number
E235
DTXSID
DTXSID6021163
PubChem CID
5284447
Evidence tier
Indexable evidence set (14)
SOURCE
EU Commission
FDA | Health Canada | Codex Alimentarius
Multi-Jurisdiction Comparison
Side-by-side status rows for the same resolved substance across public food regulators.
| Jurisdiction | Authority | Status | Evidence |
|---|---|---|---|
| European Union | EU Commission | PUBLISHED | EU additive listing; Annex II entry |
| United States | FDA | FDA has no questions | GRAS notice |
| Canada | Health Canada | Listed | Preservative |
| Codex | Codex Alimentarius | Listed | Preservative |
SOURCE
EU Commission
EU Food Additives | EU Food Additives Database
EU Food Additive Status
EU Commission food-additive listing rows from eu_food_additives.
| Jurisdiction | E-number | Status | Type | Name | Note |
|---|---|---|---|---|---|
| European Union | E235 | PUBLISHED | substanceFAD | Natamycin | - |
SOURCE
EU Commission
EU Annex II Authorised | EU Food Additives Database
EU Annex II Authorised Uses
Authorised additive rows and use conditions from EU Annex II tables.
| Jurisdiction | E-number | Name | INS | Policy item | Note |
|---|---|---|---|---|---|
| European Union | E235 | Natamycin | - | POL-FAD-IMPORT-3053 | - |
Conditions and restrictions
| Jurisdiction | Food category | Restriction | Comment | Source |
|---|---|---|---|---|
| European Union | 8.3.1 Non-heat-treated processed meat | ML 1 mg/kg | only surface treatment of dried cured sausages | EU Annex II Union List |
| European Union | 8.3.2 Heat-treated processed meat | ML 1 mg/kg | only surface treatment of dried cured sausages | EU Annex II Union List |
| European Union | 8.3.1 Non-heat-treated processed meat | ML 1 mg/kg | only surface treatment of dried cured sausages | EU Food Additives Database |
| European Union | 8.3.2 Heat-treated processed meat | ML 1 mg/kg | only surface treatment of dried cured sausages | EU Food Additives Database |
| European Union | 1.7.2 ripened cheese | ML 1 mg/dm² | surface (not present at a depth of 5 mm). Only for the external treatment of uncut hard, semi-hard and semi-soft cheese | EU Food Additives Database |
| European Union | 1.7.6 cheese products (excluding products falling in category 16) | ML 1 mg/dm² | surface (not present at a depth of 5 mm). Only for the external treatment of uncut hard, semi-hard and semi-soft cheese | EU Food Additives Database |
SOURCE
Codex Alimentarius
Codex GSFA
Codex GSFA Status
Codex Alimentarius GSFA permissions and maximum-use rows.
| Jurisdiction | INS / E-number | Function | Food category | Max level | Notes |
|---|---|---|---|---|---|
| Codex | 235 | Preservative | 01.6.1 Unripened cheese | 40 mg/kg | Excluding products conforming to the Standard for Cream Cheese (CXS 275-1973).; Excluding products conforming to the Standard for Cottage Cheese (CXS 273-1968).; Equivalent to 2... |
| Codex | 235 | Preservative | 01.6.2 Ripened cheese | 40 mg/kg | Equivalent to 2 mg/dm2 surface application to a maximum depth of 5 mm.; Excluding products conforming to the Standard for Extra Hard Grating Cheese (CXS 278-1978).; For use in... |
| Codex | 235 | Preservative | 01.6.4 Processed cheese | 40 mg/kg | Equivalent to 2 mg/dm2 surface application to a maximum depth of 5 mm.; For use in surface treatment only. |
| Codex | 235 | Preservative | 01.6.5 Cheese analogues | 40 mg/kg | Equivalent to 2 mg/dm2 surface application to a maximum depth of 5 mm.; For use in surface treatment only. |
| Codex | 235 | Preservative | 01.6.6 Whey protein cheese | 40 mg/kg | Equivalent to 2 mg/dm2 surface application to a maximum depth of 5 mm.; For use in surface treatment only. |
| Codex | 235 | Preservative | 08.2.1.2 Cured (including salted) and dried non-heat treated processed meat, poultry, and game products in whole pieces or cuts | 6 mg/kg | - |
| Codex | 235 | Preservative | 08.3.1.2 Cured (including salted) and dried non-heat treated processed comminuted meat, poultry, and game products | 20 mg/kg | For use in surface treatment only.; Equivalent to 1 mg/dm2 surface application to a maximum depth of 5 mm. |
SOURCE
FDA
FDA GRAS
FDA GRAS Status
US FDA GRAS notice evidence from enriched and notice tables.
| Jurisdiction | GRN | Substance | FDA response | Intended use | Basis | Notifier |
|---|---|---|---|---|---|---|
| United States | 517 | Natamycin | FDA has no questions | For use as an inhibitor against yeast and mold growth in yogurt at levels not to exceed 5 ppm in the finished product. | Scientific Procedures | DSM Food Specialties B.V. |
| United States | 578 | Natamycin | FDA has no questions | For use in ready-to-drink tea beverages, fruit flavored energy drinks, sport and isotonic drinks, and fruit flavored beverages at levels not to exceed 5 parts per million. | Scientific procedures | DM Food Specialties B.V |
| United States | 517 | Natamycin | FDA has no questions | For use as an inhibitor against yeast and mold growth in yogurt at levels not to exceed 5 ppm in the finished product. | Scientific Procedures | DSM Food Specialties B.V. |
| United States | 578 | Natamycin | FDA has no questions | For use in ready-to-drink tea beverages, fruit flavored energy drinks, sport and isotonic drinks, and fruit flavored beverages at levels not to exceed 5 parts per million. | Scientific procedures | DM Food Specialties B.V |
SOURCE
Health Canada
Health Canada Status
Health Canada food-additive permissions by functional class and food scope.
| Jurisdiction | Class | Permitted foods | Maximum level | List |
|---|---|---|---|---|
| Canada | Preservative | (a)Cheddar cheese; (Naming the variety) cheese | (a)Good Manufacturing Practice. To be applied to the surface of the cheese. The amount not to exceed 20 ppm in the cheese. | List of Permitted Preservatives |
| Canada | Preservative | (b) Cream cheese; Cream cheese spread; Cream cheese spread with (naming the added ingredients); Cream cheese with (naming the added ingredients); Unstandardized cream cheese products; Ranch-flavoured dips;... | (b)10 ppm | List of Permitted Preservatives |
| Canada | Preservative | (c)Grated or shredded cheddar cheese; Grated or shredded (naming the variety) cheese | (c)Good Manufacturing Practice. To be applied to the surface of the grated or shredded cheese. The amount not to exceed 10 ppm in the grated or shredded cheese. | List of Permitted Preservatives |
| Canada | Preservative | (d) Unstandardized processed cheese products | (d) 20 ppm | List of Permitted Preservatives |
SOURCE
Codex Alimentarius
Codex Pesticide MRLs
Pesticide MRLs
Codex pesticide maximum-residue-limit rows by commodity.
| Jurisdiction | Pesticide | Commodity | MRL | ADI / PTDI | ARfD | Residue definition |
|---|---|---|---|---|---|---|
| Codex | Natamycin | Acerola | 1 mg/kg | mg/kg bw Not established. | Not established | For compliance with the MRL and for estimation of dietary exposure for plant and animal commodities: Natamycin. The residue is not fat-soluble. |
SOURCE
JECFA
JECFA ADI
JECFA ADI Values
JECFA ADI records and evaluation years.
| Jurisdiction | Chemical name | JECFA no. | CAS | ADI | ADI upper | Function | Evaluation year |
|---|---|---|---|---|---|---|---|
| JECFA | PIMARICIN | - | 7681-93-8 | no_data | - | - | 2024 |
| JECFA | NATAMYCIN | - | 7681-93-8 | 0-0.3 mg/kg bw (1976) | 0.3 | PRESERVATIVE | 2024 |
SOURCE
ingredients
ghs classifications
Cross-Reference to Cosmetics / Chemicals / Pharma
Same-CAS public rows from adjacent Roots verticals where available.
SOURCE
Cross-vertical comparison
ingredients | ghs classifications
Cross-Vertical Regulatory Divergence
This substance has different regulatory treatment across food, cosmetics, and industrial use.
SOURCE
FAQPage JSON-LD
public food renderer rows
Frequently Asked Questions
Food-use, safety, ADI, and cross-vertical answers mirrored into FAQPage JSON-LD.
What is Natamycin used for in food?
Natamycin appears in food-use rows as: Preservative; Preservative; Preservative.
Is Natamycin / E235 safe?
This page does not assign a standalone safety verdict; it renders public regulatory evidence. ADI/reference value: ADI 0-0.3 mg/kg bw (1976) . EU status evidence: PUBLISHED. US/FDA evidence: FDA has no questions.
What is the ADI for Natamycin?
Natamycin has this ADI/reference value in the food-safety tables: ADI 0-0.3 mg/kg bw (1976) . Source: food_substances.
Is Natamycin also used in cosmetics?
Natamycin has a same-CAS cosmetics cross-reference: NATAMYCIN, EU status permitted.