What is the NOAEL for Iodoform?
Iodoform has 12 NOAEL studies in the database. The lowest reported value is KXI2J76489 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Iodoform
Also known as: EINECS 200-874-5, NCI-C04568, Trijodmethane, UNII-KXI2J76489
CAS 75-47-8
Iodoform (CAS 75-47-8) is a chemical substance. Key regulatory status: 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, OSHA.
Cross-Vertical Regulatory Divergence
Iodoform is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H319, H332, H336, H411, H315, H401).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
Iodoform
CAS Number
75-47-8
DTXSID
DTXSID4020743
Molecular Formula
CHI3
InChI Key
OKJPEAGHQZHRQV-UHFFFAOYSA-N
Monoisotopic Mass
393.721241
Synonyms
EINECS 200-874-5NCI-C04568TrijodmethaneUNII-KXI2J76489
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
3 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| NIOSH | TWA | 0.6 ppm (10 mg/m³) | 0.6 | 10 | N |
| ACGIH | TWA | 0.001 ppm (inhalable fraction and vapor) [2021] | 0.001 | - | Y |
| CAL/OSHA | TWA | 0.6 ppm (10 mg/m³) | 0.6 | 10 | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
BiocideFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| IFRA Transparency | IFRA | IFRA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| KXI2J76489 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| KXI2J76489 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| KXI2J76489 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| KXI2J76489 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2.6554 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 2.9451 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =355 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =71 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =213 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECOTOX |
| 55 | mg/kg bw/day | Top dose | - | Rat | NTP_ICE_cancer |
| 93 | mg/kg bw/day | Top dose | - | Mouse | NTP_ICE_cancer |
| 142 | mg/kg bw/day | Top dose | - | Rat | NTP_ICE_cancer |
Showing 12 of 12 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
IODOFORM
ChEMBL Phase
3
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include Iodoform?
Iodoform appears on 4 regulatory/inventory lists including Indirect additives food contact (10/2018), Canada; pharmaceutical, active_ingredient; Europe; Pesticides, and 1 more. Source: EPA CPDat.
What are the occupational exposure limits for Iodoform?
Occupational exposure limits for Iodoform are set by NIOSH, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Iodoform used in cosmetics?
Yes, Iodoform is also indexed as a cosmetic ingredient under the name Iodoform. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Iodoform come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Iodoform have different safety status in cosmetics vs industrial chemicals?
Iodoform is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H319, H332, H336, H411, H315, H401).
Is Iodoform used outside industrial chemicals?
Iodoform also appears in cosmetics, pharmaceutical databases.