Danger GHS02GHS08GHS07 NOAEL Data IARC Group 1 Prop 65 REACH Registered Cosmetic Ingredient

Acetaldehyde

Also known as: Ethanal, Acetic ethanol, Acetylaldehyde, EINECS 200-836-8, FEMA No. 2003 (+8 more)

CAS 75-07-0

Acetaldehyde (CAS 75-07-0) is a chemical substance with GHS signal word Danger; key hazard signal: H224; H350; H341; H335; H319. Key regulatory status: California Proposition 65, REACH registered, 58 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, SCCS, IARC, ECHA REACH, CA Prop 65, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for ACETALDEHYDE →

Cross-Vertical Regulatory Divergence

Acetaldehyde is classified GHS Danger (H224, H350, H341, H335, H319) in the chemicals database but is restricted in EU cosmetics at max II/1391.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 19 fields

Name

Acetaldehyde

CAS Number

75-07-0

DTXSID

DTXSID5039224

Molecular Formula

C2H4O

InChI Key

IKHGUXGNUITLKF-UHFFFAOYSA-N

Monoisotopic Mass

44.026215

Synonyms

EthanalAcetic ethanolAcetylaldehydeEINECS 200-836-8FEMA No. 2003NCI-C56326RCRA waste number U001Aldehyde acetiqueAldeide aceticaOctowy aldehydUNII-GO1N1ZPR3BAldehyde

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 2 records

Group	Meaning	Evaluated	Volume
Group 1	Carcinogenic to humans	2009	100E
Group 2B	Possibly carcinogenic	1998	36, Sup 7, 71

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records

Chemical	Toxicity Type	Cancer	Developmental	Listed
-	cancer	Yes	No	-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Flam. Liq. 1; Carc. 1B; Muta. 2; STOT SE 3; Eye Irrit. 2	H224; H350; H341; H335; H319	GHS02; GHS08; GHS07	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance is mildly irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system.
Long-term Effects	Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the respiratory tract. This may result in tissue lesions. This substance is possibly carcinogenic to humans.
Routes of Exposure	The substance can be absorbed into the body by inhalation and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 6 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	200 ppm (360 mg/m³)	200	360	N
CAL/OSHA	CEILING	25 ppm (45 mg/m³)	25	45	N
NIOSH	IDLH	2000 ppm	2000	-	-
AIHA	ERPG-1	10 ppm	10	-	-
AIHA	ERPG-2	200 ppm	200	-	-
AIHA	ERPG-3	1000 ppm	1000	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 41 records

DeodorizerSoftener and conditionerProcessing aids not otherwise specifiedFlavouring and nutrientCorrosion inhibitorBinderNo specific technical functionFragranceSolvent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 58 records

List	Keyword	Source
Canada; consumer_product; Substances in Products - Canada (4/2014)	Government of Canada	CPCat
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; consumer_product; detected; emissions	Elsevier	CPCat
consumer_product; detected	Elsevier	CPCat
air; Cleaning products and household care - laundry and fabric treatment; detected; emissions	Elsevier	CPCat
air; detected; emissions; Personal care	Elsevier	CPCat
air; Cleaning products and household care - air freshener; detected; emissions	Elsevier	CPCat
OEHHA Proposition 65 (3/2019)	STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY	OEHHA Proposition 65 List
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; Batteries; Cons electronics mech appliances and machinery; emissions; Europe; Other direct contact consumer goods; Other indirect contact consumer goods; Toys and children's products	Ministry of Environment and Food of Denmark; Environmental Protection Agency	Danish EPA
air; Cleaning products and household care - air freshener; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - air freshener; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cleaning products and household care - air freshener; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; Batteries; emissions; Europe; nondetect	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 93 studies

Value	Unit	Endpoint	Route	Species	Source
5	ppm	-	inhalation	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
400	ppm	-	inhalation	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
500	mg/kg bw/day	-	-	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=178	mg/m3	BMC (05)	inhalation	Rat	ToxValDB_Cal_OEHHA_REL_derivations
SQEinhalation=90	ug/day	California Proposition 65 NSRL	-	-	California Proposition 65
SQEinhalation=90	ug/day	California Proposition 65 NSRL	-	-	California Proposition 65
SQEinhalation=90	ug/day	California Proposition 65 NSRL	-	-	California Proposition 65
SQEcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
SQEcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
SQEcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
GO1N1ZPR3B	UNII	FDA UNII substance identifier	-	-	openFDA substances
GO1N1ZPR3B	UNII	FDA UNII substance identifier	-	-	openFDA substances
GO1N1ZPR3B	UNII	FDA UNII substance identifier	-	-	openFDA substances
GO1N1ZPR3B	UNII	FDA UNII substance identifier	-	-	openFDA substances
1	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
2B	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
2	unitless	IARC group	-	-	NTP_ICE_cancer
0.0000022	ug/m3	Inhalation risk unit	Inhalation	-	NTP_ICE_cancer
23.9485	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
24	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
25	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
37	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
37.3092	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=661	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=1930	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=125	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ECHA_IUCLID
=675	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ECHA_IUCLID
=72070.7	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=142	mg/m3	LOAEL	inhalation	Human	ToxValDB_Cal_OEHHA_REL_derivations
675	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
=728	mg/m3	LOAEL	inhalation	Rat	ToxValDB_IRIS
=130	mg/m3	LOAEL (ADJ)	inhalation	Rat	ToxValDB_IRIS
=16.9	mg/m3	LOAEL (HEC)	inhalation	Rat	ToxValDB_IRIS
=50	mg/100 mL	LOEL	environmental	Mouse	ToxValDB_ECOTOX
=675	mg/kg bw	LOEL	-	-	INCHEM_WHO_ehc_ehc_ehc167
=675	mg/kg bw	LOEL	-	-	INCHEM_WHO_ehc_ehc_ehc167
=0.5	mg/kg bw/d	NOAEL	dermal	rat	SCCS_vision_codex
=0.5	mg/kg bw/d	NOAEL	dermal	rat	SCCS_vision_codex
=0.5	mg/kg bw/d	NOAEL	dermal	rat	SCCS_vision_codex
=0.5	mg/kg bw/d	NOAEL	dermal	rat	SCCS_vision_codex
=5	ppm	NOAEL	inhalation	rat	SCCS_vision_codex
=5	ppm	NOAEL	inhalation	rat	SCCS_vision_codex
=5	ppm	NOAEL	inhalation	rat	SCCS_vision_codex
=5	ppm	NOAEL	inhalation	rat	SCCS_vision_codex
10	mg/kg bw/day	NOAEL	oral	guinea pig	COSMOS_DB
=120	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=120	mg/kg bw/day	NOAEL	oral: drinking water	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
125	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=125	mg/kg bw/d	NOAEL	inhalation	-	SCCS_vision_codex
=125	mg/kg bw/d	NOAEL	inhalation	-	SCCS_vision_codex

Showing 50 of 93 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Acetaldehyde	200-836-8	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
Acetaldehyde	-	-

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1474/12	18 September 2012	not safe	Not safe in cosmetic products	Carcinogen (IARC Group 1); mutagenic; reproductive toxicity; irritant

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

II/1391

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL ACETALDEHYDE

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Acetaldehyde?

Acetaldehyde (CAS 75-07-0) is classified under EU CLP Annex VI as Flam. Liq. 1; Carc. 1B; Muta. 2; STOT SE 3; Eye Irrit. 2 with signal word Danger. Hazard statements: H224; H350; H341; H335; H319. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Acetaldehyde?

Acetaldehyde has 93 NOAEL studies in the database. The lowest reported value is 0.009 mg/m3 via inhalation in Human. Source: ToxValDB_IRIS.

What regulatory lists include Acetaldehyde?

Acetaldehyde appears on 30 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), air; Cons electronics mech appliances and machinery; detected; emissions; Europe, Cons electronics mech appliances and machinery; detected; emissions; Europe, and 27 more. Source: EPA CPDat.

Is Acetaldehyde a carcinogen according to IARC?

Acetaldehyde is classified by IARC as Group 1 — carcinogenic to humans (evaluated 2009). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is Acetaldehyde on the California Proposition 65 list?

Yes, Acetaldehyde is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.

What are the occupational exposure limits for Acetaldehyde?

Occupational exposure limits for Acetaldehyde are set by OSHA, CAL/OSHA, NIOSH. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Acetaldehyde used in cosmetics?

Yes, Acetaldehyde is also indexed as a cosmetic ingredient under the name ACETALDEHYDE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Acetaldehyde come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Acetaldehyde have different safety status in cosmetics vs industrial chemicals?

Acetaldehyde is classified GHS Danger (H224, H350, H341, H335, H319) in the chemicals database but is restricted in EU cosmetics at max II/1391.

Is Acetaldehyde used outside industrial chemicals?

Acetaldehyde also appears in cosmetics, pharmaceutical, food safety, cannabis databases.