Danger GHS02GHS08GHS07 NOAEL Data IARC Group 1 Prop 65 REACH Registered Cosmetic Ingredient

Acetaldehyde

Also known as: Ethanal, Acetic ethanol, Acetylaldehyde, EINECS 200-836-8, FEMA No. 2003 (+8 more)

CAS 75-07-0

Acetaldehyde (CAS 75-07-0) is a chemical substance with GHS signal word Danger; key hazard signal: H224; H350; H341; H335; H319. Key regulatory status: California Proposition 65, REACH registered, 58 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, SCCS, IARC, ECHA REACH, CA Prop 65, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for ACETALDEHYDE →

SOURCE noael studies public
NOAEL studies
93
SOURCE chemical inventory jurisdictions
Regulatory lists
58
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 19 fields
Name
Acetaldehyde
CAS Number
75-07-0
DTXSID
DTXSID5039224
Molecular Formula
C2H4O
InChI Key
IKHGUXGNUITLKF-UHFFFAOYSA-N
Monoisotopic Mass
44.026215
Synonyms
EthanalAcetic ethanolAcetylaldehydeEINECS 200-836-8FEMA No. 2003NCI-C56326RCRA waste number U001Aldehyde acetiqueAldeide aceticaOctowy aldehydUNII-GO1N1ZPR3BAldehyde

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 2 records
GroupMeaningEvaluatedVolume
Group 1Carcinogenic to humans2009100E
Group 2BPossibly carcinogenic199836, Sup 7, 71

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records
ChemicalToxicity TypeCancerDevelopmentalListed
-cancerYesNo-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Flam. Liq. 1; Carc. 1B; Muta. 2; STOT SE 3; Eye Irrit. 2H224; H350; H341; H335; H319GHS02; GHS08; GHS07Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
Short-term EffectsThe substance is mildly irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system.
Long-term EffectsRepeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the respiratory tract. This may result in tissue lesions. This substance is possibly carcinogenic to humans.
Routes of ExposureThe substance can be absorbed into the body by inhalation and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 6 records
AgencyMetricValueppmmg/m3Skin
OSHATWA200 ppm (360 mg/m³)200360N
CAL/OSHACEILING25 ppm (45 mg/m³)2545N
NIOSHIDLH2000 ppm2000--
AIHAERPG-110 ppm10--
AIHAERPG-2200 ppm200--
AIHAERPG-31000 ppm1000--

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 41 records
DeodorizerSoftener and conditionerProcessing aids not otherwise specifiedFlavouring and nutrientCorrosion inhibitorBinderNo specific technical functionFragranceSolvent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 58 records
ListKeywordSource
Canada; consumer_product; Substances in Products - Canada (4/2014)Government of CanadaCPCat
air; Cons electronics mech appliances and machinery; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
Cons electronics mech appliances and machinery; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
air; consumer_product; detected; emissionsElsevierCPCat
consumer_product; detectedElsevierCPCat
air; Cleaning products and household care - laundry and fabric treatment; detected; emissionsElsevierCPCat
air; detected; emissions; Personal careElsevierCPCat
air; Cleaning products and household care - air freshener; detected; emissionsElsevierCPCat
OEHHA Proposition 65 (3/2019)STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCYOEHHA Proposition 65 List
air; detected; emissions; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
air; Batteries; Cons electronics mech appliances and machinery; emissions; Europe; Other direct contact consumer goods; Other indirect contact consumer goods; Toys and children's productsMinistry of Environment and Food of Denmark; Environmental Protection AgencyDanish EPA
air; Cleaning products and household care - air freshener; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - air freshener; EuropeDanish Environmental Protection AgencyDanish EPA
air; Cleaning products and household care - air freshener; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
air; Batteries; emissions; Europe; nondetectDanish Environmental Protection AgencyDanish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 93 studies
ValueUnitEndpointRouteSpeciesSource
5ppm-inhalationratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
400ppm-inhalationratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
500mg/kg bw/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=178mg/m3BMC (05)inhalationRatToxValDB_Cal_OEHHA_REL_derivations
SQEinhalation=90ug/dayCalifornia Proposition 65 NSRL--California Proposition 65
SQEinhalation=90ug/dayCalifornia Proposition 65 NSRL--California Proposition 65
SQEinhalation=90ug/dayCalifornia Proposition 65 NSRL--California Proposition 65
SQEcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
SQEcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
SQEcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
GO1N1ZPR3BUNIIFDA UNII substance identifier--openFDA substances
GO1N1ZPR3BUNIIFDA UNII substance identifier--openFDA substances
GO1N1ZPR3BUNIIFDA UNII substance identifier--openFDA substances
GO1N1ZPR3BUNIIFDA UNII substance identifier--openFDA substances
1IARC groupIARC carcinogenicity classification--IARC Monographs
2BIARC groupIARC carcinogenicity classification--IARC Monographs
2unitlessIARC group--NTP_ICE_cancer
0.0000022ug/m3Inhalation risk unitInhalation-NTP_ICE_cancer
23.9485mg/LLC50Inhalation-NTP_ICE_acute_inhalation
24mg/LLC50Inhalation-NTP_ICE_acute_inhalation
25mg/LLC50Inhalation-NTP_ICE_acute_inhalation
37mg/LLC50Inhalation-NTP_ICE_acute_inhalation
37.3092mg/LLC50Inhalation-NTP_ICE_acute_inhalation
=661mg/kg bwLD50oralRatNTP_ICE_acute_oral
=1930mg/kg bwLD50oralRatNTP_ICE_acute_oral
=125mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
=675mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
=72070.7mg/m3LELinhalationHumanToxValDB_DOE_Protective_Action_Criteria
=142mg/m3LOAELinhalationHumanToxValDB_Cal_OEHHA_REL_derivations
675mg/kg bw/dayLOAELoralratCOSMOS_DB
=728mg/m3LOAELinhalationRatToxValDB_IRIS
=130mg/m3LOAEL (ADJ)inhalationRatToxValDB_IRIS
=16.9mg/m3LOAEL (HEC)inhalationRatToxValDB_IRIS
=50mg/100 mLLOELenvironmentalMouseToxValDB_ECOTOX
=675mg/kg bwLOEL--INCHEM_WHO_ehc_ehc_ehc167
=675mg/kg bwLOEL--INCHEM_WHO_ehc_ehc_ehc167
=0.5mg/kg bw/dNOAELdermalratSCCS_vision_codex
=0.5mg/kg bw/dNOAELdermalratSCCS_vision_codex
=0.5mg/kg bw/dNOAELdermalratSCCS_vision_codex
=0.5mg/kg bw/dNOAELdermalratSCCS_vision_codex
=5ppmNOAELinhalationratSCCS_vision_codex
=5ppmNOAELinhalationratSCCS_vision_codex
=5ppmNOAELinhalationratSCCS_vision_codex
=5ppmNOAELinhalationratSCCS_vision_codex
10mg/kg bw/dayNOAELoralguinea pigCOSMOS_DB
=120mg/kg bw/dayNOAELoralRatToxValDB_EFSA
=120mg/kg bw/dayNOAELoral: drinking waterRatEFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
125mg/kg bw/dayNOAELoralratCOSMOS_DB
=125mg/kg bw/dNOAELinhalation-SCCS_vision_codex
=125mg/kg bw/dNOAELinhalation-SCCS_vision_codex

Showing 50 of 93 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredAcetaldehyde200-836-8ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records
ChemicalCategoryFlags
Acetaldehyde--

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1474/1218 September 2012not safeNot safe in cosmetic productsCarcinogen (IARC Group 1); mutagenic; reproductive toxicity; irritant

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
II/1391
Category
Fragrance
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL ACETALDEHYDE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Acetaldehyde?

Acetaldehyde (CAS 75-07-0) is classified under EU CLP Annex VI as Flam. Liq. 1; Carc. 1B; Muta. 2; STOT SE 3; Eye Irrit. 2 with signal word Danger. Hazard statements: H224; H350; H341; H335; H319. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Acetaldehyde?

Acetaldehyde has 93 NOAEL studies in the database. The lowest reported value is 0.009 mg/m3 via inhalation in Human. Source: ToxValDB_IRIS.

What regulatory lists include Acetaldehyde?

Acetaldehyde appears on 30 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), air; Cons electronics mech appliances and machinery; detected; emissions; Europe, Cons electronics mech appliances and machinery; detected; emissions; Europe, and 27 more. Source: EPA CPDat.

Is Acetaldehyde a carcinogen according to IARC?

Acetaldehyde is classified by IARC as Group 1 — carcinogenic to humans (evaluated 2009). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is Acetaldehyde on the California Proposition 65 list?

Yes, Acetaldehyde is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.

What are the occupational exposure limits for Acetaldehyde?

Occupational exposure limits for Acetaldehyde are set by OSHA, CAL/OSHA, NIOSH. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Acetaldehyde used in cosmetics?

Yes, Acetaldehyde is also indexed as a cosmetic ingredient under the name ACETALDEHYDE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Acetaldehyde come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Acetaldehyde have different safety status in cosmetics vs industrial chemicals?

Acetaldehyde is classified GHS Danger (H224, H350, H341, H335, H319) in the chemicals database but is restricted in EU cosmetics at max II/1391.

Is Acetaldehyde used outside industrial chemicals?

Acetaldehyde also appears in cosmetics, pharmaceutical, food safety, cannabis databases.