Also known as: As, Arsenicals, Colloidal arsenic, EINECS 231-148-6, Gray arsenic (+6 more)
CAS 7440-38-2
Arsenic (CAS 7440-38-2) is a chemical substance with GHS signal word Danger; key hazard signal: H331; H301; H400; H410. Key regulatory status: REACH registered, 49 regulatory/inventory lists; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC, OSHA, EPA TRI.
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 1 | Carcinogenic to humans | 2009 | 23, Sup 7, 100C |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 3 *; Acute Tox. 3 *; Aquatic Acute 1; Aquatic Chronic 1 | H331; H301; H400; H410 | GHS06; GHS09 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Toxic if swallowed May cause cancer Suspected of damaging fertility or the unborn child Causes damage to the gastrointestinal tract if swallowed Causes damage to organs through prolonged or repeated exposure Toxic to aquatic life with long lasting effects |
| Short-term Effects | The substance may cause effects on the gastrointestinal tract. This may result in severe gastroenteritis, loss of fluids and electrolytes, cardiac disorders, shock and convulsions. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated. |
| Long-term Effects | The substance may have effects on the skin, mucous membranes, peripheral nervous system, liver and bone marrow. This may result in pigmentation disorders, hyperkeratosis, perforation of the nasal septum, neuropathy, anaemia and liver impairment. This substance is carcinogenic to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 10 µg/m³ [5 µg/m³ Action Level] | - | - | N |
| NIOSH | CEILING | 0.002 mg/m³ [15 minutes] | - | 0.002 | N |
| CAL/OSHA | TWA | 0.01 mg/m³ [0.005 mg/m³ Action Level] | - | 0.01 | N |
| NIOSH | IDLH | 5 mg/m³ | - | 5 | - |
| OSHA | TWA | 0.5 mg/m³ | - | 0.5 | N |
| CAL/OSHA | TWA | 0.2 mg/m³ | - | 0.2 | N |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Europe; pharmaceutical | European Medicines Agency | PROTECT ADR database |
| detected; Europe; Personal care - make-up and related - eye liner | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| detected; Israel; Toys and children's products | Chemosphere | Published Articles |
| - | Journal of Chemical Engineering & Process Technology | Published Articles |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| Personal care; prohibited; Southeast Asia | Asean | ASEAN Cosmetics |
| fracking; water | NY Department of Conservation | CPCat |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| children | Vermont Department of Health | State of Vermont |
| children; WA Children's Safe Product Act (4/2020) | State of Washington Department of Ecology | State of Washington |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| banned; Europe; Personal care | European Commission | CosIng |
| Pesticides | National Park Service | CPCat |
| artificial_sweat; emissions; Europe; nondetect; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Europe; nondetect; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.003 | mg/kg bw/day | BMDL (0.5) | oral | Human | ToxValDB_WHO_JECFA_Tox_Studies |
| =0.0052 | mg/kg bw/day | BMDL (0.5) | oral | Human | ToxValDB_WHO_JECFA_Tox_Studies |
| =0.0054 | mg/kg bw/day | BMDL (0.5) | oral | Human | ToxValDB_WHO_JECFA_Tox_Studies |
| =0.004 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| N712M78A8G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N712M78A8G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N712M78A8G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N712M78A8G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 1 | unitless | IARC group | - | - | NTP_ICE_cancer |
| 0.0043 | ug/m3 | Inhalation risk unit | Inhalation | - | NTP_ICE_cancer |
| =0.014 | mg/kg bw/day | LOAEL | oral | Human | ToxValDB_IRIS |
| =0.05 | mg/kg bw/day | LOAEL | oral | Human | ToxValDB_ATSDR_MRLs |
| =0.05 | mg/kg/day | LOAEL | oral | Human (M/F) | ATSDR_toxval_ATSDR_MRLs.xlsx |
| =0.23 | ug As/m3 | LOAEL | oral | Human | ToxValDB_Cal_OEHHA_REL_derivations |
| =0.26 | mg/m3 | LOAEL | inhalation | Mouse | ToxValDB_Cal_OEHHA_REL_derivations |
| =0.704 | mg/L | LOEL | oral | Mouse | ToxValDB_ECOTOX |
| =0.0003 | mg/kg bw/day | MRL | oral | Human | ToxValDB_ATSDR_MRLs |
| =0.0003 | mg/kg bw/day | MRL | oral | Human | ToxValDB_ATSDR_MRLs |
| =0.005 | mg/kg bw/day | MRL | oral | Human | ToxValDB_ATSDR_MRLs |
| =0.005 | mg/kg bw/day | MRL | oral | Human | ToxValDB_ATSDR_MRLs |
| =0.0008 | mg/kg bw/day | NOAEL | oral | Human | ToxValDB_ATSDR_MRLs |
| =0.0008 | mg/kg/day | NOAEL | oral | Human (M/F) | ATSDR_toxval_ATSDR_MRLs.xlsx |
| =0.75 | mg/kg bw/day | NOAEL | - | Mouse; Rabbit | INCHEM_WHO_ehc_ehc_ehc224 |
| =7.5 | mg/kg bw/day | NOAEL | - | Mouse; Rabbit | INCHEM_WHO_ehc_ehc_ehc224 |
| =10 | mg/m3 | NOAEL | - | - | INCHEM_WHO_ehc_ehc_ehc224 |
| 1.5 | mg/kg bw/day | Oral slope factor | Oral | - | NTP_ICE_cancer |
| =0.000015 | mg/m3 | RfC | inhalation | Human | ToxValDB_RSL |
| =0.00006 | mg/kg/day | RfD | oral | - | EPA_IRIS_iris_rfd_systems.csv |
Showing 29 of 29 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Arsenic | 231-148-6 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| Arsenic | - | - |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
ADI: 1 mg/kg bw
View full food safety profile →Same-CAS cannabis compliance and lab records where available.
5 cannabis records found in cannabis contaminant tests (heavy_metal) across Massachusetts.
View full cannabis profile →Arsenic (CAS 7440-38-2) is classified under EU CLP Annex VI as Acute Tox. 3 *; Acute Tox. 3 *; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H331; H301; H400; H410. Source: EU CLP Annex VI (ECHA).
Arsenic has 29 NOAEL studies in the database. The lowest reported value is 0.003 mg/kg bw/day via oral in Human. Source: ToxValDB_WHO_JECFA_Tox_Studies.
Arsenic appears on 23 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), pharmaceutical, Europe; pharmaceutical, and 20 more. Source: EPA CPDat.
Arsenic is classified by IARC as Group 1 — carcinogenic to humans (evaluated 2009). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Occupational exposure limits for Arsenic are set by OSHA, NIOSH, CAL/OSHA. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Arsenic also appears in pharmaceutical, food safety, cannabis databases.